Circumvention of human tumor drug resistance

Kevin J. Scanlon, Lawrence Sowers

Research output: Contribution to journalArticle

Abstract

A method involving the administration of nucleoside analogs to circumvent resistance attributable to the enhanced DNA repair capacity of cancer cells is described. The nucleoside analogs function as suicide substrates for DNA repair enzymes. A method of screening nucleoside analogs for utility as antitumor agents and a screening assay to individual recurrent tumors is described.

Original languageEnglish (US)
Pages (from-to)701
Number of pages1
JournalBiotechnology Advances
Volume15
Issue number3-4
StatePublished - 1997
Externally publishedYes

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Nucleosides
Drug Resistance
Tumors
Screening
Pharmaceutical Preparations
DNA Repair Enzymes
Neoplasms
DNA Repair
Antineoplastic Agents
Suicide
Assays
DNA
Repair
Cells
Substrates

ASJC Scopus subject areas

  • Biotechnology

Cite this

Circumvention of human tumor drug resistance. / Scanlon, Kevin J.; Sowers, Lawrence.

In: Biotechnology Advances, Vol. 15, No. 3-4, 1997, p. 701.

Research output: Contribution to journalArticle

Scanlon, Kevin J. ; Sowers, Lawrence. / Circumvention of human tumor drug resistance. In: Biotechnology Advances. 1997 ; Vol. 15, No. 3-4. pp. 701.
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