Cis-acting genomic elements and trans-acting proteins involved in the assembly of rna viruses

Sondra Schlesinger, Shinji Makino, Maxine L. Linial

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

There is now considerable evidence that a specific site (or sites) in the genome of an RNA virus interacts with a viral protein to initiate the assembly of the virus ribonucleoprotein or nucleocapsid. We describe the progress that has been made in defining these elements for a number of different viruses: the togavirus, Sindbis virus; the coronavirus, mouse hepatitis virus; influenza A virus; several retroviruses; and the hepadnavirus, hepatitis B virus. The importance of cis-acting elements in packaging has been established for all of these viruses. For Sindbis virus, specificity in the binding of the RNA element to a region of the viral capsid protein in vitro has also been demonstrated.

Original languageEnglish (US)
Pages (from-to)39-49
Number of pages11
JournalSeminars in Virology
Volume5
Issue number1
DOIs
StatePublished - Feb 1994

Keywords

  • Packaging signals
  • RNA structures
  • RNA-protein binding

ASJC Scopus subject areas

  • Immunology
  • Virology

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