Cisapride in children with chronic intestinal pseudoobstruction. An acute, double-blind, crossover, placebo-controlled trial

Carlo Di Lorenzo, S. Narasimha Reddy, Javier Villanueva-Meyer, Ismael Mena, Shelley Martin, Paul E. Hyman

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

To assess the effect of cisapride on gastrointestinal motility and gastric emptying in children with chronic intestinal pseudoobstruction, 20 children (mean age, 4.9 years; 14 female and 6 male) who required special means of alimentation or who had severe symptoms confirmed by diary during 2 weeks before the study were studied. A motility catheter with recording sites in the antrum and duodenum was placed on the first day of the study and remained in place until the end of the 5-day study. Cisapride (0.3 mg/kg PO t.i.d.) or placebo was given in double-blind randomized crossover fashion, with a 2-day "washout" interval. Antroduodenal motility was recorded on days 2 and 5. Recording consisted of 4 hours of fasting and 2 hours after a complex liquid meal labeled with 99mTc. Gastric emptying was assessed for 1 hour after the meal. Based on manometry, 16 patients had neuropathic and 4 patients had myopathic disorders. Cisapride had no effect on the discrete, qualitative abnormalities found in individual records. Cisapride increased the postprandial duodenal motility index from 1180 ± 256 mm Hg/30 min after placebo to 2385 ± 430 mm Hg/30 min (P < 0.05) but had no significant effect on the antral motility index. Cisapride did not alter the profound delay in gastric emptying; time to reach 50% of initial activity (T 1 2) was 105 ± 20 vs. 93 ± 19 minutes and percentage of retention after 60 minutes (R60) 56% ± 4% vs. 58% ± 4% in control vs. cisapride, respectively. In summary, in children with chronic intestinal pseudoobstruction, cisapride increased postprandial duodenal motility but did not improve gastric emptying.

Original languageEnglish (US)
Pages (from-to)1564-1570
Number of pages7
JournalGastroenterology
Volume101
Issue number6
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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