Cisapride in children with chronic intestinal pseudoobstruction. An acute, double-blind, crossover, placebo-controlled trial

Carlo Di Lorenzo, S. Narasimha Reddy, Javier Villanueva-Meyer, Ismael Mena, Shelley Martin, Paul E. Hyman

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

To assess the effect of cisapride on gastrointestinal motility and gastric emptying in children with chronic intestinal pseudoobstruction, 20 children (mean age, 4.9 years; 14 female and 6 male) who required special means of alimentation or who had severe symptoms confirmed by diary during 2 weeks before the study were studied. A motility catheter with recording sites in the antrum and duodenum was placed on the first day of the study and remained in place until the end of the 5-day study. Cisapride (0.3 mg/kg PO t.i.d.) or placebo was given in double-blind randomized crossover fashion, with a 2-day "washout" interval. Antroduodenal motility was recorded on days 2 and 5. Recording consisted of 4 hours of fasting and 2 hours after a complex liquid meal labeled with 99mTc. Gastric emptying was assessed for 1 hour after the meal. Based on manometry, 16 patients had neuropathic and 4 patients had myopathic disorders. Cisapride had no effect on the discrete, qualitative abnormalities found in individual records. Cisapride increased the postprandial duodenal motility index from 1180 ± 256 mm Hg/30 min after placebo to 2385 ± 430 mm Hg/30 min (P < 0.05) but had no significant effect on the antral motility index. Cisapride did not alter the profound delay in gastric emptying; time to reach 50% of initial activity (T 1 2) was 105 ± 20 vs. 93 ± 19 minutes and percentage of retention after 60 minutes (R60) 56% ± 4% vs. 58% ± 4% in control vs. cisapride, respectively. In summary, in children with chronic intestinal pseudoobstruction, cisapride increased postprandial duodenal motility but did not improve gastric emptying.

Original languageEnglish (US)
Pages (from-to)1564-1570
Number of pages7
JournalGastroenterology
Volume101
Issue number6
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Cisapride
Intestinal Pseudo-Obstruction
Placebos
Gastric Emptying
Meals
Gastrointestinal Motility
Manometry
Duodenum
Fasting
Catheters

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Cisapride in children with chronic intestinal pseudoobstruction. An acute, double-blind, crossover, placebo-controlled trial. / Lorenzo, Carlo Di; Reddy, S. Narasimha; Villanueva-Meyer, Javier; Mena, Ismael; Martin, Shelley; Hyman, Paul E.

In: Gastroenterology, Vol. 101, No. 6, 01.01.1991, p. 1564-1570.

Research output: Contribution to journalArticle

Lorenzo, Carlo Di ; Reddy, S. Narasimha ; Villanueva-Meyer, Javier ; Mena, Ismael ; Martin, Shelley ; Hyman, Paul E. / Cisapride in children with chronic intestinal pseudoobstruction. An acute, double-blind, crossover, placebo-controlled trial. In: Gastroenterology. 1991 ; Vol. 101, No. 6. pp. 1564-1570.
@article{836b967cbb92458eb8d5779d9bf88100,
title = "Cisapride in children with chronic intestinal pseudoobstruction. An acute, double-blind, crossover, placebo-controlled trial",
abstract = "To assess the effect of cisapride on gastrointestinal motility and gastric emptying in children with chronic intestinal pseudoobstruction, 20 children (mean age, 4.9 years; 14 female and 6 male) who required special means of alimentation or who had severe symptoms confirmed by diary during 2 weeks before the study were studied. A motility catheter with recording sites in the antrum and duodenum was placed on the first day of the study and remained in place until the end of the 5-day study. Cisapride (0.3 mg/kg PO t.i.d.) or placebo was given in double-blind randomized crossover fashion, with a 2-day {"}washout{"} interval. Antroduodenal motility was recorded on days 2 and 5. Recording consisted of 4 hours of fasting and 2 hours after a complex liquid meal labeled with 99mTc. Gastric emptying was assessed for 1 hour after the meal. Based on manometry, 16 patients had neuropathic and 4 patients had myopathic disorders. Cisapride had no effect on the discrete, qualitative abnormalities found in individual records. Cisapride increased the postprandial duodenal motility index from 1180 ± 256 mm Hg/30 min after placebo to 2385 ± 430 mm Hg/30 min (P < 0.05) but had no significant effect on the antral motility index. Cisapride did not alter the profound delay in gastric emptying; time to reach 50{\%} of initial activity (T 1 2) was 105 ± 20 vs. 93 ± 19 minutes and percentage of retention after 60 minutes (R60) 56{\%} ± 4{\%} vs. 58{\%} ± 4{\%} in control vs. cisapride, respectively. In summary, in children with chronic intestinal pseudoobstruction, cisapride increased postprandial duodenal motility but did not improve gastric emptying.",
author = "Lorenzo, {Carlo Di} and Reddy, {S. Narasimha} and Javier Villanueva-Meyer and Ismael Mena and Shelley Martin and Hyman, {Paul E.}",
year = "1991",
month = "1",
day = "1",
doi = "10.1016/0016-5085(91)90393-Y",
language = "English (US)",
volume = "101",
pages = "1564--1570",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Cisapride in children with chronic intestinal pseudoobstruction. An acute, double-blind, crossover, placebo-controlled trial

AU - Lorenzo, Carlo Di

AU - Reddy, S. Narasimha

AU - Villanueva-Meyer, Javier

AU - Mena, Ismael

AU - Martin, Shelley

AU - Hyman, Paul E.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - To assess the effect of cisapride on gastrointestinal motility and gastric emptying in children with chronic intestinal pseudoobstruction, 20 children (mean age, 4.9 years; 14 female and 6 male) who required special means of alimentation or who had severe symptoms confirmed by diary during 2 weeks before the study were studied. A motility catheter with recording sites in the antrum and duodenum was placed on the first day of the study and remained in place until the end of the 5-day study. Cisapride (0.3 mg/kg PO t.i.d.) or placebo was given in double-blind randomized crossover fashion, with a 2-day "washout" interval. Antroduodenal motility was recorded on days 2 and 5. Recording consisted of 4 hours of fasting and 2 hours after a complex liquid meal labeled with 99mTc. Gastric emptying was assessed for 1 hour after the meal. Based on manometry, 16 patients had neuropathic and 4 patients had myopathic disorders. Cisapride had no effect on the discrete, qualitative abnormalities found in individual records. Cisapride increased the postprandial duodenal motility index from 1180 ± 256 mm Hg/30 min after placebo to 2385 ± 430 mm Hg/30 min (P < 0.05) but had no significant effect on the antral motility index. Cisapride did not alter the profound delay in gastric emptying; time to reach 50% of initial activity (T 1 2) was 105 ± 20 vs. 93 ± 19 minutes and percentage of retention after 60 minutes (R60) 56% ± 4% vs. 58% ± 4% in control vs. cisapride, respectively. In summary, in children with chronic intestinal pseudoobstruction, cisapride increased postprandial duodenal motility but did not improve gastric emptying.

AB - To assess the effect of cisapride on gastrointestinal motility and gastric emptying in children with chronic intestinal pseudoobstruction, 20 children (mean age, 4.9 years; 14 female and 6 male) who required special means of alimentation or who had severe symptoms confirmed by diary during 2 weeks before the study were studied. A motility catheter with recording sites in the antrum and duodenum was placed on the first day of the study and remained in place until the end of the 5-day study. Cisapride (0.3 mg/kg PO t.i.d.) or placebo was given in double-blind randomized crossover fashion, with a 2-day "washout" interval. Antroduodenal motility was recorded on days 2 and 5. Recording consisted of 4 hours of fasting and 2 hours after a complex liquid meal labeled with 99mTc. Gastric emptying was assessed for 1 hour after the meal. Based on manometry, 16 patients had neuropathic and 4 patients had myopathic disorders. Cisapride had no effect on the discrete, qualitative abnormalities found in individual records. Cisapride increased the postprandial duodenal motility index from 1180 ± 256 mm Hg/30 min after placebo to 2385 ± 430 mm Hg/30 min (P < 0.05) but had no significant effect on the antral motility index. Cisapride did not alter the profound delay in gastric emptying; time to reach 50% of initial activity (T 1 2) was 105 ± 20 vs. 93 ± 19 minutes and percentage of retention after 60 minutes (R60) 56% ± 4% vs. 58% ± 4% in control vs. cisapride, respectively. In summary, in children with chronic intestinal pseudoobstruction, cisapride increased postprandial duodenal motility but did not improve gastric emptying.

UR - http://www.scopus.com/inward/record.url?scp=0026046847&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026046847&partnerID=8YFLogxK

U2 - 10.1016/0016-5085(91)90393-Y

DO - 10.1016/0016-5085(91)90393-Y

M3 - Article

VL - 101

SP - 1564

EP - 1570

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 6

ER -