Citrulline does not relax isolated rat and rabbit vessels

Stephen Marx, Yuri Vedernikov, George R. Saade, Robert E. Garfield

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


1. The study was prompted by the report of Ruiz E. and Tejerina T., describing endothelium-independent relaxation by L-citrulline via activation of particulate guanylate cyclase. 2. We compared the effects of L-citrulline and L-arginine in isolated aortic rings of rats and in isolated aortic, carotid and femoral artery rings of rabbits. 3. No significant relaxation to either L-citrulline or L-arginine was found in the concentration range of 10-12 to 10-3 M, while 3-morpholinosydnonimine hydrochloride (SIN-1, 10-6 M) relaxed vascular tissues. 4. This study does not support the conclusion that L-citrulline has direct vasorelaxing action on vascular smooth muscle.

Original languageEnglish (US)
Pages (from-to)713-716
Number of pages4
JournalBritish Journal of Pharmacology
Issue number4
StatePublished - 2000
Externally publishedYes


  • 3-Morpholinosydnonimine hydrochloride (SIN-1)
  • L-arginine
  • L-citrulline
  • Relaxation
  • Vascular smooth muscle

ASJC Scopus subject areas

  • Pharmacology


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