Civamide (cis-capsaicin) for treatment of primary or recurrent experimental genital herpes

Nigel Bourne, D. I. Bernstein, L. R. Stanberry

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Neuropharmacologic agents able to disrupt normal virus-neuron interactions may provide an alternative strategy for the treatment of herpes simplex virus (HSV) infections. We have previously shown that prophylactic treatment with capsaicin, a natural compound that alters function in sensory neurons, can protect guinea pigs against cutaneous HSV disease, even though the compound has no direct antiviral activity. Here we have examined the ability of civamide, the cis isomer of capsaicin, to interfere with HSV disease. We show that, even when the onset of treatment was delayed until after intravaginal virus challenge, primary genital skin disease severity was significantly reduced. In addition, animals treated during primary infection subsequently experienced a long-lasting reduction in recurrent disease. Civamide treatment during latent infection also significantly reduced recurrent disease, although for a shorter period. Further a single weekly treatment with civamide during latent infection was sufficient to reduce recurrent disease, indicating that an infrequent suppressive maintenance therapy might be possible.

Original languageEnglish (US)
Pages (from-to)2685-2688
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume43
Issue number11
StatePublished - 1999
Externally publishedYes

Fingerprint

Herpes Genitalis
Capsaicin
Virus Diseases
Simplexvirus
Infection
Viruses
Sensory Receptor Cells
Skin Diseases
Antiviral Agents
Guinea Pigs
Neurons
Skin
zucapsaicin
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Civamide (cis-capsaicin) for treatment of primary or recurrent experimental genital herpes. / Bourne, Nigel; Bernstein, D. I.; Stanberry, L. R.

In: Antimicrobial Agents and Chemotherapy, Vol. 43, No. 11, 1999, p. 2685-2688.

Research output: Contribution to journalArticle

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