Clarithromycin for Safe and Cost-Effective Reduction of Cyclosporine Doses in Lung Allograft Recipients

Mark T. Knower, Kathy Labella-Walker, P. Michael McFadden, Stephen P. Kantrow, Vincent G. Valentine

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Abstract

Background. This study was done to analyze the economic effect of clarithromycin on the daily dosing of cyclosporine in lung transplantation. Methods. Nine consecutive patients (mean age ± SEM, 34.6 ± 5.2 years) had transplantation from June 1995 to June 1996. Median follow-up time was 649 days (range, 431 to 799 days). Preoperative diagnoses were cystic fibrosis (n = 4), idiopathic pulmonary fibrosis (n = 2), emphysema, bronchiectasis, and obliterative bronchiolitis. Median time from transplantation to addition of clarithromycin to a standard immunosuppressive regimen was 86 days (range, 14 to 181 days). Results. Baseline cyclosporine dose (9.9 ± 2.2 mg/kg/day) was reduced to 5.8 ± 1.0 mg/kg/day and 4.1 ± 0.8 mg/kg/day at 1 month and 1 year, respectively, after initiation of clarithromycin therapy. Estimated annual savings were $3,400 per patient. There was no increase in infection or rejection episodes. Conclusions. Clarithromycin safely reduced the dose and cost of cyclosporine in this series.

Original languageEnglish (US)
Pages (from-to)1087-1092
Number of pages6
JournalSouthern Medical Journal
Volume93
Issue number11
StatePublished - Nov 2000
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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Knower, M. T., Labella-Walker, K., McFadden, P. M., Kantrow, S. P., & Valentine, V. G. (2000). Clarithromycin for Safe and Cost-Effective Reduction of Cyclosporine Doses in Lung Allograft Recipients. Southern Medical Journal, 93(11), 1087-1092.