Class II MHC-expressing myofibroblasts play a role in the immunopathogenesis associated with staphylococcal enterotoxins

C. A. Barrera, I. V. Pinchuk, J. I. Saada, G. Suarez, D. A. Bland, E. Beswick, P. A. Adegboyega, R. C. Mifflin, D. W. Powell, V. E. Reyes

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Food poisoning due to staphylococcal enterotoxins (SEs) affects hundreds of thousands of people each year. Little is known about how SEs initiate immune responses and cause pathogenesis. Here, we demonstrate that cultured human intestinal myofibroblasts (IMFs) bind SEs in an MHC class II-dependent fashion. IMFs respond to SE exposure with increased secretion of IL-6, IL-8, and TNF-α. A significant proliferative T cell response was observed when MHC class II-expressing IMFs were pulsed with SEA and cocultured with human CD4 + T cells. In conclusion, our findings support the hypothesis that IMFs may play an important role in pathology associated with staphlococcocal enterotoxigenic disease.

Original languageEnglish (US)
Pages (from-to)313-318
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume1029
DOIs
StatePublished - Jan 1 2004

Keywords

  • Cytokines
  • MHC class II molecule
  • Myofibroblast
  • Staphylococcal enterotoxins
  • Superantigen

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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    Barrera, C. A., Pinchuk, I. V., Saada, J. I., Suarez, G., Bland, D. A., Beswick, E., Adegboyega, P. A., Mifflin, R. C., Powell, D. W., & Reyes, V. E. (2004). Class II MHC-expressing myofibroblasts play a role in the immunopathogenesis associated with staphylococcal enterotoxins. Annals of the New York Academy of Sciences, 1029, 313-318. https://doi.org/10.1196/annals.1309.022