Clear cell hidradenoma: a mimic of metastatic clear cell tumors.

Keith E. Volmar, Thomas J. Cummings, Wei Hua Wang, Andrew J. Creager, Douglas S. Tyler, H. Bill Xie

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Clear cell hidradenoma is a benign skin appendage tumor that may mimic conventional-type renal cell carcinoma. Histologically, clear cell hidradenoma contains small ductular lumens, focal apocrine and squamoid change, and a less prominent vascular pattern than renal cell carcinoma. Furthermore, immunohistochemical studies can aid in distinguishing the 2 tumors. Knowing the cytologic features of primary skin adnexal neoplasms helps distinguish them from cutaneous metastases, which are more commonly referred for fine-needle aspiration biopsy evaluation. Detailed clinical history, physical findings, and ancillary studies are essential for correct diagnosis and categorization of these tumors. We report the rare case of a patient with renal cell carcinoma who underwent excision of an axillary clear cell hidradenoma, which was clinically suggestive of cutaneous metastatic disease.

Original languageEnglish (US)
Pages (from-to)e113-116
JournalArchives of pathology & laboratory medicine
Issue number5
StatePublished - May 2005
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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