Clearance of Persistent SARS-CoV-2 RNA Detection in a NFκB-Deficient Patient in Association with the Ingestion of Human Breast Milk: A Case Report

Janine S. Sabino; Mariene R. Amorim; William M. de Souza; Lia F. Marega; Luciana S. Mofatto; Daniel A. Toledo-Teixeira; Julia Forato; Rodrigo G. Stabeli; Maria Laura Costa; Fernando R. Spilki; Ester C. Sabino; Nuno R. Faria; Bruno D. Benites; Marcelo Addas-Carvalho; Raquel S.B. Stucchi; Dewton M. Vasconcelos; Scott C. Weaver; Fabiana Granja; José Luiz Proenca-Modena; Maria Marluce Dos S. Vilela

doi:10.3390/v14051042

Clearance of Persistent SARS-CoV-2 RNA Detection in a NFκB-Deficient Patient in Association with the Ingestion of Human Breast Milk: A Case Report

Janine S. Sabino, Mariene R. Amorim, William M. de Souza, Lia F. Marega, Luciana S. Mofatto, Daniel A. Toledo-Teixeira, Julia Forato, Rodrigo G. Stabeli, Maria Laura Costa, Fernando R. Spilki, Ester C. Sabino, Nuno R. Faria, Bruno D. Benites, Marcelo Addas-Carvalho, Raquel S.B. Stucchi, Dewton M. Vasconcelos, Scott C. Weaver, Fabiana Granja, José Luiz Proenca-Modena, Maria Marluce Dos S. Vilela

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immuno-suppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essential role against respiratory virus infection in mucosa cells, being, in addition, more potent in neutralizing SARS-CoV-2 than IgG, here we report the clinical course of an NFκB-deficient patient chronically infected with the SARS-CoV-2 Gamma variant, who, after a non-full effective treatment with plasma infusion, received breast milk from a vaccinated mother by oral route as treatment for COVID-19. After such treatment, the symptoms improved, and the patient was systematically tested negative for SARS-CoV-2. Thus, we hypothesize that IgA and IgG secreted antibodies present in breast milk could be useful to treat persistent SARS-CoV-2 infection in immunodeficient patients.

Original language	English (US)
Article number	1042
Journal	Viruses
Volume	14
Issue number	5
DOIs	https://doi.org/10.3390/v14051042
State	Published - May 2022

Keywords

IgA
NFκB-deficiency
breast milk
immunosuppression
persistent SARS-CoV-2 infection

ASJC Scopus subject areas

Infectious Diseases
Virology

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10.3390/v14051042

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Sabino, J. S., Amorim, M. R., de Souza, W. M., Marega, L. F., Mofatto, L. S., Toledo-Teixeira, D. A., Forato, J., Stabeli, R. G., Costa, M. L., Spilki, F. R., Sabino, E. C., Faria, N. R., Benites, B. D., Addas-Carvalho, M., Stucchi, R. S. B., Vasconcelos, D. M., Weaver, S. C., Granja, F., Proenca-Modena, J. L., & Vilela, M. M. D. S. (2022). Clearance of Persistent SARS-CoV-2 RNA Detection in a NFκB-Deficient Patient in Association with the Ingestion of Human Breast Milk: A Case Report. Viruses, 14(5), Article 1042. https://doi.org/10.3390/v14051042

Sabino, JS, Amorim, MR, de Souza, WM, Marega, LF, Mofatto, LS, Toledo-Teixeira, DA, Forato, J, Stabeli, RG, Costa, ML, Spilki, FR, Sabino, EC, Faria, NR, Benites, BD, Addas-Carvalho, M, Stucchi, RSB, Vasconcelos, DM, Weaver, SC, Granja, F, Proenca-Modena, JL & Vilela, MMDS 2022, 'Clearance of Persistent SARS-CoV-2 RNA Detection in a NFκB-Deficient Patient in Association with the Ingestion of Human Breast Milk: A Case Report', Viruses, vol. 14, no. 5, 1042. https://doi.org/10.3390/v14051042

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abstract = "Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immuno-suppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essential role against respiratory virus infection in mucosa cells, being, in addition, more potent in neutralizing SARS-CoV-2 than IgG, here we report the clinical course of an NFκB-deficient patient chronically infected with the SARS-CoV-2 Gamma variant, who, after a non-full effective treatment with plasma infusion, received breast milk from a vaccinated mother by oral route as treatment for COVID-19. After such treatment, the symptoms improved, and the patient was systematically tested negative for SARS-CoV-2. Thus, we hypothesize that IgA and IgG secreted antibodies present in breast milk could be useful to treat persistent SARS-CoV-2 infection in immunodeficient patients.",

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AU - de Souza, William M.

AU - Marega, Lia F.

AU - Mofatto, Luciana S.

AU - Toledo-Teixeira, Daniel A.

AU - Forato, Julia

AU - Stabeli, Rodrigo G.

AU - Costa, Maria Laura

AU - Spilki, Fernando R.

AU - Sabino, Ester C.

AU - Faria, Nuno R.

AU - Benites, Bruno D.

AU - Addas-Carvalho, Marcelo

AU - Stucchi, Raquel S.B.

AU - Vasconcelos, Dewton M.

AU - Weaver, Scott C.

AU - Granja, Fabiana

AU - Proenca-Modena, José Luiz

AU - Vilela, Maria Marluce Dos S.

PY - 2022/5

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N2 - Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immuno-suppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essential role against respiratory virus infection in mucosa cells, being, in addition, more potent in neutralizing SARS-CoV-2 than IgG, here we report the clinical course of an NFκB-deficient patient chronically infected with the SARS-CoV-2 Gamma variant, who, after a non-full effective treatment with plasma infusion, received breast milk from a vaccinated mother by oral route as treatment for COVID-19. After such treatment, the symptoms improved, and the patient was systematically tested negative for SARS-CoV-2. Thus, we hypothesize that IgA and IgG secreted antibodies present in breast milk could be useful to treat persistent SARS-CoV-2 infection in immunodeficient patients.

AB - Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immuno-suppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essential role against respiratory virus infection in mucosa cells, being, in addition, more potent in neutralizing SARS-CoV-2 than IgG, here we report the clinical course of an NFκB-deficient patient chronically infected with the SARS-CoV-2 Gamma variant, who, after a non-full effective treatment with plasma infusion, received breast milk from a vaccinated mother by oral route as treatment for COVID-19. After such treatment, the symptoms improved, and the patient was systematically tested negative for SARS-CoV-2. Thus, we hypothesize that IgA and IgG secreted antibodies present in breast milk could be useful to treat persistent SARS-CoV-2 infection in immunodeficient patients.

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KW - breast milk

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Clearance of Persistent SARS-CoV-2 RNA Detection in a NFκB-Deficient Patient in Association with the Ingestion of Human Breast Milk: A Case Report

Abstract

Keywords

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