Clinical and histological effects of the intrathecal administration of methylprednisolone in dogs

Rodrigo Moreira Lima, Lais H. Navarro, Jeffrey M. Carness, Guilherme A. Barros, Mariangela E A Marques, Daneshvari Solanki, Eliana M. Ganem

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: Methylprednisolone is one of the most commonly used steroids for management of chronic back pain via epidural injection. Its inadvertent injection into the intrathecal space is associated with complications such as adhesive arachnoiditis. Objective: The present study aimed to assess the clinical and histological changes associated with the injection of methylprednisolone into the intrathecal space of dogs. Study Design: A randomized, double blind, controlled animal trial. Methods: After approval by the animal research ethics committee, 14 dogs were studied in a randomized double blind controlled trial. They were assigned to one of 2 groups: Group I received 1 mL of 0.9% normal saline; Group II received 1 mL (1.15mg/kg) of methylprednisolone into the intrathecal space. Animals were clinically evaluated for 21 days, and then sacrificed. The lumbar and sacral portions of their spinal cords were removed for histological examination. Results: In Group I, there were no clinical or histological changes. All animals in Group II showed no clinical changes but all exhibited histological changes in the spinal cord. The main histological changes consisted of meningeal thickening and lymphocytic infiltrates in the blood vessels. In 3 animals, adhesion of pia, arachnoid, and dura matter was noted and the nerve roots were surrounded by fibrosis. In one animal, necrosis of the spinal cord was evident. Limitations: The limitations of the present study include: small sample of animals (n=14), relative short clinical follow-up (21 days), and use of a commercially available drug solution, which is not preservative free. Conclusion: The present study demonstrated that the intrathecal administration of commercially available methylprednisolone was responsible for causing histological changes in the spinal cord and meninges of the animals studied.

Original languageEnglish (US)
Pages (from-to)493-501
Number of pages9
JournalPain Physician
Volume13
Issue number5
StatePublished - Sep 2010

Fingerprint

Methylprednisolone
Dogs
Spinal Cord
Animal Care Committees
Arachnoiditis
Arachnoid
Epidural Injections
Spinal Injections
Meninges
Research Ethics Committees
Back Pain
Chronic Pain
Adhesives
Blood Vessels
Fibrosis
Necrosis
Steroids
Injections
Pharmaceutical Preparations

Keywords

  • Adhesive arachnoiditis
  • Epidural injection
  • Intrathecal injection
  • Low back pain
  • Methylprednisolone
  • Spinal cord
  • Steroids

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Lima, R. M., Navarro, L. H., Carness, J. M., Barros, G. A., Marques, M. E. A., Solanki, D., & Ganem, E. M. (2010). Clinical and histological effects of the intrathecal administration of methylprednisolone in dogs. Pain Physician, 13(5), 493-501.

Clinical and histological effects of the intrathecal administration of methylprednisolone in dogs. / Lima, Rodrigo Moreira; Navarro, Lais H.; Carness, Jeffrey M.; Barros, Guilherme A.; Marques, Mariangela E A; Solanki, Daneshvari; Ganem, Eliana M.

In: Pain Physician, Vol. 13, No. 5, 09.2010, p. 493-501.

Research output: Contribution to journalArticle

Lima, RM, Navarro, LH, Carness, JM, Barros, GA, Marques, MEA, Solanki, D & Ganem, EM 2010, 'Clinical and histological effects of the intrathecal administration of methylprednisolone in dogs', Pain Physician, vol. 13, no. 5, pp. 493-501.
Lima RM, Navarro LH, Carness JM, Barros GA, Marques MEA, Solanki D et al. Clinical and histological effects of the intrathecal administration of methylprednisolone in dogs. Pain Physician. 2010 Sep;13(5):493-501.
Lima, Rodrigo Moreira ; Navarro, Lais H. ; Carness, Jeffrey M. ; Barros, Guilherme A. ; Marques, Mariangela E A ; Solanki, Daneshvari ; Ganem, Eliana M. / Clinical and histological effects of the intrathecal administration of methylprednisolone in dogs. In: Pain Physician. 2010 ; Vol. 13, No. 5. pp. 493-501.
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AU - Solanki, Daneshvari

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