Clinical and Research Tools for the Study of Cardiovascular Effects of Cancer Therapy

Rafey A. Feroze, Jeff Leya, Todd Herron, Salim S. Hayek

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


The expansion of cancer therapeutics has paved the way for improved cancer-related outcomes. Cardiotoxicity from cancer therapy occurs in a small but significant subset of patients, is often poorly understood, and contributes to adverse outcomes at all stages of cancer treatment. Given the often-idiopathic occurrence of cardiotoxicity, novel strategies are needed for risk-stratification and early identification of cancer patients experiencing cardiotoxicity. Clinical and research tools extending from imaging to blood-based biomarkers and pluripotent stem cells are being explored as methods to study the cardiovascular impact of various cancer treatments. Here we provide an overview of tools currently available for evaluation of cardiotoxicity and highlight novel techniques in development aimed at understanding underlying pathophysiologic mechanisms.

Original languageEnglish (US)
Pages (from-to)417-430
Number of pages14
JournalJournal of Cardiovascular Translational Research
Issue number3
StatePublished - Jun 1 2020
Externally publishedYes


  • Biomarkers
  • Cardiac CT
  • Cardiac MRI
  • Cardio-oncology
  • Cardiotoxicity
  • Nuclear imaging

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)


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