Clinical characteristics of patients in Peru with human T cell lymphotropic virus type 1-associated tropical spastic paraparesis

Eduardo Gotuzzo, J. Cabrera, L. Daze, K. Verdonck, A. M. Vandamme, R. Cairampoma, D. Vizcarra, M. Cabada, G. Narvarte, C. De Las Casas

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Background. Human T cell lymphotropic virus type 1 (HTLV-1) is associated with tropical spastic paraparesis (TSP). Peru is an area of endemicity for HTLV-1. Methods. All patients with suspected cases of TSP referred to our institute (Institute of Tropical Medicine Alexander von Humboldt, Lima, Peru) from 1989 through 2002 were interviewed and tested for HTLV-1. All patients with positive results were evaluated by an expert physician. Disease progression was defined as "rapid" if the time between TSP onset and inability to walk unaided was <2 years. Results. Among 165 patients enrolled, the symptoms and signs most frequently found were spasticity (in 97.5% of patients), hyperreflexia (95.4%), lower limb paresthesia (90.2%), pyramidal signs (82.6%), urinary complaints (82.0%), and lumbar pain (79.0%). Rapid progression was present in 21.5% of patients; mean age at TSP onset was higher among these patients than among slow progressors (P<.001). Severe spasticity, diminished vibratory sensation, and tremor were found more frequently among rapid progressors, compared with slow progressors. Conclusions. HTLV-1-associated TSP is frequently diagnosed in areas of HTLV-1-endemicity. A subgroup of patients experiences rapid disease progression.

Original languageEnglish (US)
Pages (from-to)939-944
Number of pages6
JournalClinical Infectious Diseases
Volume39
Issue number7
DOIs
StatePublished - Oct 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Gotuzzo, E., Cabrera, J., Daze, L., Verdonck, K., Vandamme, A. M., Cairampoma, R., Vizcarra, D., Cabada, M., Narvarte, G., & De Las Casas, C. (2004). Clinical characteristics of patients in Peru with human T cell lymphotropic virus type 1-associated tropical spastic paraparesis. Clinical Infectious Diseases, 39(7), 939-944. https://doi.org/10.1086/423957