Clinical characteristics of patients in Peru with human T cell lymphotropic virus type 1-associated tropical spastic paraparesis

Eduardo Gotuzzo, J. Cabrera, L. Daze, K. Verdonck, A. M. Vandamme, R. Cairampoma, D. Vizcarra, Miguel Cabada, G. Narvarte, C. De Las Casas

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Background. Human T cell lymphotropic virus type 1 (HTLV-1) is associated with tropical spastic paraparesis (TSP). Peru is an area of endemicity for HTLV-1. Methods. All patients with suspected cases of TSP referred to our institute (Institute of Tropical Medicine Alexander von Humboldt, Lima, Peru) from 1989 through 2002 were interviewed and tested for HTLV-1. All patients with positive results were evaluated by an expert physician. Disease progression was defined as "rapid" if the time between TSP onset and inability to walk unaided was <2 years. Results. Among 165 patients enrolled, the symptoms and signs most frequently found were spasticity (in 97.5% of patients), hyperreflexia (95.4%), lower limb paresthesia (90.2%), pyramidal signs (82.6%), urinary complaints (82.0%), and lumbar pain (79.0%). Rapid progression was present in 21.5% of patients; mean age at TSP onset was higher among these patients than among slow progressors (P<.001). Severe spasticity, diminished vibratory sensation, and tremor were found more frequently among rapid progressors, compared with slow progressors. Conclusions. HTLV-1-associated TSP is frequently diagnosed in areas of HTLV-1-endemicity. A subgroup of patients experiences rapid disease progression.

Original languageEnglish (US)
Pages (from-to)939-944
Number of pages6
JournalClinical Infectious Diseases
Volume39
Issue number7
DOIs
StatePublished - Oct 1 2004
Externally publishedYes

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Tropical Spastic Paraparesis
Peru
Human T-lymphotropic virus 1
T-Lymphocytes
Disease Progression
Tropical Medicine
Abnormal Reflexes
Paresthesia
Tremor
Signs and Symptoms
Lower Extremity
Physicians
Pain

ASJC Scopus subject areas

  • Immunology

Cite this

Gotuzzo, E., Cabrera, J., Daze, L., Verdonck, K., Vandamme, A. M., Cairampoma, R., ... De Las Casas, C. (2004). Clinical characteristics of patients in Peru with human T cell lymphotropic virus type 1-associated tropical spastic paraparesis. Clinical Infectious Diseases, 39(7), 939-944. https://doi.org/10.1086/423957

Clinical characteristics of patients in Peru with human T cell lymphotropic virus type 1-associated tropical spastic paraparesis. / Gotuzzo, Eduardo; Cabrera, J.; Daze, L.; Verdonck, K.; Vandamme, A. M.; Cairampoma, R.; Vizcarra, D.; Cabada, Miguel; Narvarte, G.; De Las Casas, C.

In: Clinical Infectious Diseases, Vol. 39, No. 7, 01.10.2004, p. 939-944.

Research output: Contribution to journalArticle

Gotuzzo, E, Cabrera, J, Daze, L, Verdonck, K, Vandamme, AM, Cairampoma, R, Vizcarra, D, Cabada, M, Narvarte, G & De Las Casas, C 2004, 'Clinical characteristics of patients in Peru with human T cell lymphotropic virus type 1-associated tropical spastic paraparesis', Clinical Infectious Diseases, vol. 39, no. 7, pp. 939-944. https://doi.org/10.1086/423957
Gotuzzo, Eduardo ; Cabrera, J. ; Daze, L. ; Verdonck, K. ; Vandamme, A. M. ; Cairampoma, R. ; Vizcarra, D. ; Cabada, Miguel ; Narvarte, G. ; De Las Casas, C. / Clinical characteristics of patients in Peru with human T cell lymphotropic virus type 1-associated tropical spastic paraparesis. In: Clinical Infectious Diseases. 2004 ; Vol. 39, No. 7. pp. 939-944.
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AU - Vandamme, A. M.

AU - Cairampoma, R.

AU - Vizcarra, D.

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N2 - Background. Human T cell lymphotropic virus type 1 (HTLV-1) is associated with tropical spastic paraparesis (TSP). Peru is an area of endemicity for HTLV-1. Methods. All patients with suspected cases of TSP referred to our institute (Institute of Tropical Medicine Alexander von Humboldt, Lima, Peru) from 1989 through 2002 were interviewed and tested for HTLV-1. All patients with positive results were evaluated by an expert physician. Disease progression was defined as "rapid" if the time between TSP onset and inability to walk unaided was <2 years. Results. Among 165 patients enrolled, the symptoms and signs most frequently found were spasticity (in 97.5% of patients), hyperreflexia (95.4%), lower limb paresthesia (90.2%), pyramidal signs (82.6%), urinary complaints (82.0%), and lumbar pain (79.0%). Rapid progression was present in 21.5% of patients; mean age at TSP onset was higher among these patients than among slow progressors (P<.001). Severe spasticity, diminished vibratory sensation, and tremor were found more frequently among rapid progressors, compared with slow progressors. Conclusions. HTLV-1-associated TSP is frequently diagnosed in areas of HTLV-1-endemicity. A subgroup of patients experiences rapid disease progression.

AB - Background. Human T cell lymphotropic virus type 1 (HTLV-1) is associated with tropical spastic paraparesis (TSP). Peru is an area of endemicity for HTLV-1. Methods. All patients with suspected cases of TSP referred to our institute (Institute of Tropical Medicine Alexander von Humboldt, Lima, Peru) from 1989 through 2002 were interviewed and tested for HTLV-1. All patients with positive results were evaluated by an expert physician. Disease progression was defined as "rapid" if the time between TSP onset and inability to walk unaided was <2 years. Results. Among 165 patients enrolled, the symptoms and signs most frequently found were spasticity (in 97.5% of patients), hyperreflexia (95.4%), lower limb paresthesia (90.2%), pyramidal signs (82.6%), urinary complaints (82.0%), and lumbar pain (79.0%). Rapid progression was present in 21.5% of patients; mean age at TSP onset was higher among these patients than among slow progressors (P<.001). Severe spasticity, diminished vibratory sensation, and tremor were found more frequently among rapid progressors, compared with slow progressors. Conclusions. HTLV-1-associated TSP is frequently diagnosed in areas of HTLV-1-endemicity. A subgroup of patients experiences rapid disease progression.

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