Clinical effects of inhibiting leukocyte adhesion with monoclonal antibody to intercellular adhesion molecule-1 (enlimomab) in the treatment of partial-thickness burn injury

William J. Mileski, Deborah Burkhart, John L. Hunt, Richard J. Kagan, Jeffrey R. Saffle, David M. Heimbach, David N. Herndon, Arnold Luterman, Roger W. Yurt, Cleon W. Goodwin, John Hansborough

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42 Scopus citations

Abstract

Background: A randomized, prospective, multicenter, double-blind, placebo-controlled, phase II clinical trial was performed to determine whether inhibition of leukocyte adherence by administration of monoclonal antibody directed against intercellular adhesion molecule-1 would improve burn wound healing. Methods: One hundred ten patients with burn injury ranging from 10% to 30% total body surface area were enrolled. Fifty-six patients received placebo (saline) and 54 patients received murine monoclonal antibody to the human intercellular adhesion molecule-1 (enlimomab). Treatment was initiated within 6 hours of injury. Patients had three distinct partial-thickness woundsites assessed. LaserDoppler flowmetry was used to stratify wounds on the day of injury. Wounds were assessed for healing status on day 21 postburn and categorized as healed, nonhealed, or grafted. Results: Patients treated with enlimomab had asignificantly increased percentage of wounds thathealed spontaneously in less than 21 days overall and when stratified by burn wound laser Doppler blood flow readings for those wounds at greatest risk for nonhealing.Conclusion These Results support the concept that leukocyte adherence is involved in the pathogenesis of burn wound necrosis and suggest a therapeutic mechanism for modulating the inflammatory response after the burn injurythat may improve wound healing.

Original languageEnglish (US)
Pages (from-to)950-958
Number of pages9
JournalJournal of Trauma
Volume52
Issue number5
DOIs
StatePublished - May 2003

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Keywords

  • Burns
  • Intercellular adhesion molecule-1(ICAM-1)
  • Laser Doppler
  • Leukocyte adherence

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

Cite this

Mileski, W. J., Burkhart, D., Hunt, J. L., Kagan, R. J., Saffle, J. R., Heimbach, D. M., Herndon, D. N., Luterman, A., Yurt, R. W., Goodwin, C. W., & Hansborough, J. (2003). Clinical effects of inhibiting leukocyte adhesion with monoclonal antibody to intercellular adhesion molecule-1 (enlimomab) in the treatment of partial-thickness burn injury. Journal of Trauma, 52(5), 950-958. https://doi.org/10.1097/01.TA.0000030626.84680.11