Clinical Evaluation of an Acellular Allograft Dermal Matrix in Full-Thickness Burns

David Wainwright, Michael Madden, Arnold Luterman, John Hunt, William Monafo, David Heimbach, Richard Kagan, Kevin Sittig, Alan Dimick, David Herndon

Research output: Contribution to journalArticle

350 Scopus citations

Abstract

A multicenter clinical study assessed the ability of an acellular allograft dermal matrix to function as a permanent dermal transplant in full-thickness and deep partial-thickness burns. The study consisted of a pilot phase (24 patients) to identify the optimum protocol and a study phase (43 patients) to evaluate graft performance. Each patient had both a test and a mirror-image or contiguous control site. At the test site, the dermal matrix was grafted to the excised wound base and a split-thickness autograft was simultaneously applied over it. The control site was grafted with a split-thickness autograft alone. Fourteen-day take rates of the dermal matrix were statistically equivalent to the control autografts. Histology of the dermal matrix showed fibroblast infiltration, neovascularization, and neoepithelialization without evidence of rejection. Wound assessment over time showed that thin split-thickness autografts plus allograft dermal matrix were equivalent to thicker split-thickness autografts.

Original languageEnglish (US)
Pages (from-to)124-136
Number of pages13
JournalJournal of Burn Care and Rehabilitation
Volume17
Issue number2
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Surgery
  • Nursing(all)
  • Emergency Medicine
  • Rehabilitation
  • Health Professions(all)

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    Wainwright, D., Madden, M., Luterman, A., Hunt, J., Monafo, W., Heimbach, D., Kagan, R., Sittig, K., Dimick, A., & Herndon, D. (1996). Clinical Evaluation of an Acellular Allograft Dermal Matrix in Full-Thickness Burns. Journal of Burn Care and Rehabilitation, 17(2), 124-136. https://doi.org/10.1097/00004630-199603000-00006