Clinical laboratory, virologic, and pathologic changes in hamsters experimentally infected with pirital virus (Arenaviridae): A rodent model of Lassa fever

Elena Sbrana, Rosa I. Mateo, Shu Yuan Xiao, Vsevolod Popov, Patrick C. Newman, Robert B. Tesh

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The clinical laboratory, virologic, and pathologic changes occurring in hamsters after infection with Pirital virus (Arenaviridae) are described. Pirital virus infection in the hamsters was characterized by high titered viremia, leukocytosis, coagulopathy, pulmonary hemorrhage and edema, hepatocellular and splenic necrosis, and marked elevation of serum transaminase levels. All of the animals died within 9 days. The clinical and histopathological findings in the Pirital virus-infected hamsters were very similar to those reported in severe human cases of Lassa fever, suggesting that this new animal model could serve as a low-cost and relatively safe alternative for studying the pathogenesis and therapy of Lassa fever.

Original languageEnglish (US)
Pages (from-to)1096-1102
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume74
Issue number6
StatePublished - Jun 2006

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Arenaviridae
New World Arenaviruses
Lassa Fever
Cricetinae
Rodentia
Viremia
Leukocytosis
Virus Diseases
Pulmonary Edema
Transaminases
Necrosis
Animal Models
Hemorrhage
Costs and Cost Analysis
Infection
Serum

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Clinical laboratory, virologic, and pathologic changes in hamsters experimentally infected with pirital virus (Arenaviridae) : A rodent model of Lassa fever. / Sbrana, Elena; Mateo, Rosa I.; Xiao, Shu Yuan; Popov, Vsevolod; Newman, Patrick C.; Tesh, Robert B.

In: American Journal of Tropical Medicine and Hygiene, Vol. 74, No. 6, 06.2006, p. 1096-1102.

Research output: Contribution to journalArticle

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