Clinical manifestations and management of pediatric HIV infection

Dinesh Kaul, Janak Patel

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

HIV infection has emerged as a colossal problem with epidemic proportions. According to an estimate from UNAIDS about 36.1 million people all over the world are infected at present. In India about 3.5 million people are infected. The infection has evolved into phase II process of disease evolution, spreading from high-risk population to the general population. The antenatal HIV seropositivity has shown a steady increase from 0.1% to 2% in some tertiary care hospitals in Mumbai. Pediatric HIV infection presents with diverse clinical manifestations. In developing countries like India, diagnosis of infection during first year of life in perinatally exposed infants poses a problem due to lack of easy accessibility and increased cost of diagnostic facilities like HIV-PCR, CD4/CD8 counts and viral cultures. Moreover, lack of adequate drugs and exorbitant cost of sustaining antiretroviral therapy complicates the management issues. An assortment of antiretovirals is available in USA and other developed countries. In India drugs like zidovudine, lamivudine, stavudine, nevirapine and indinavir are available and are used in symptomatic patients. CDC has defined definite treatment guidelines for pediatric population recently. These guidelines need to be modified in our set up. At the present juncture in India the emphasis remains on the prevention and treatment of opportunistic infections like tuberculosis and pneumocystis carinii and on prevention of perinatal transmission with zidovudine. This brief review deals with various clinical manifestations as relevantin a developing country like India and recent advances in antiretroviral therapy.

Original languageEnglish (US)
Pages (from-to)623-631
Number of pages9
JournalIndian Journal of Pediatrics
Volume68
Issue number7
StatePublished - Jul 2001

Fingerprint

HIV Infections
India
Pediatrics
Zidovudine
Developing Countries
Guidelines
HIV Seropositivity
Population
Indinavir
Pneumocystis carinii
Drug Costs
Opportunistic Infections
Tertiary Healthcare
Therapeutics
Centers for Disease Control and Prevention (U.S.)
CD4 Lymphocyte Count
Infection
Developed Countries
Tertiary Care Centers
Tuberculosis

Keywords

  • HIV infection in children
  • Treatment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Clinical manifestations and management of pediatric HIV infection. / Kaul, Dinesh; Patel, Janak.

In: Indian Journal of Pediatrics, Vol. 68, No. 7, 07.2001, p. 623-631.

Research output: Contribution to journalArticle

Kaul, Dinesh ; Patel, Janak. / Clinical manifestations and management of pediatric HIV infection. In: Indian Journal of Pediatrics. 2001 ; Vol. 68, No. 7. pp. 623-631.
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