Clinical prediction model for differentiation of disseminated Histoplasma capsulatum and Mycobacterium avium complex infections in febrile patients with AIDS

Edward A. Graviss, Elizabeth A. Vanden Heuvel, Christine E. Lacke, Steven A. Spindel, A. Clinton White, Richard J. Hamill

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Disseminated infection with Histoplasma capsulatum and Mycobacterium avium complex (MAC) in patients with AIDS are frequently difficult to distinguish clinically. Methods: We retrospectively compared demographic information, other opportunistic infections, medications, symptoms, physical examination findings and laboratory parameters at the time of hospital presentation for 32 patients with culture documented disseminated histoplasmosis and 58 patients with disseminated MAC infection. Results: Positive predictors of histoplasma infection by univariate analysis included lactate dehydrogenase level, white blood cell (WBC) count, platelet count, alkaline phosphatase level, and CD4 cell count. By multivariate logistic regression analysis, those characteristics that remained significant included a lactate dehydrogenase value ≥500 U/L (risk ratio [RR], 42; 95% confidence interval [CI], 18.53-97.5; p < .001), alkaline phosphatase ≤300 U/L (RR, 9.35; 95% CI, 2.61-33.48; p = .008), WBC ≤4.5 x 106/L (RR, 21.29; 95% CI, 6.79-66.75; p = .008), and CD4 cell count (RR, 0.958; 95% CI, 0.946-0.971; p = .001). Conclusions: A predictive model for distinguishing disseminated histoplasmosis from MAC infection was developed using lactate dehydrogenase and alkaline phosphatase levels as well as WBC count. This model had a sensitivity of 83%, a specificity of 91%, and a misclassification rate of 13%.

Original languageEnglish (US)
Pages (from-to)30-36
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Volume24
Issue number1
StatePublished - May 1 2000
Externally publishedYes

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Histoplasma
Mycobacterium avium Complex
Acquired Immunodeficiency Syndrome
Fever
Odds Ratio
L-Lactate Dehydrogenase
Confidence Intervals
Alkaline Phosphatase
Histoplasmosis
CD4 Lymphocyte Count
Infection
Leukocyte Count
Opportunistic Infections
Platelet Count
Physical Examination
Leukocytes
Logistic Models
Regression Analysis
Demography

Keywords

  • Clinical prediction model
  • Disseminated histoplasmosis
  • Disseminated Mycobacterium avium complex infection
  • HIV

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Clinical prediction model for differentiation of disseminated Histoplasma capsulatum and Mycobacterium avium complex infections in febrile patients with AIDS. / Graviss, Edward A.; Vanden Heuvel, Elizabeth A.; Lacke, Christine E.; Spindel, Steven A.; White, A. Clinton; Hamill, Richard J.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 24, No. 1, 01.05.2000, p. 30-36.

Research output: Contribution to journalArticle

Graviss, Edward A. ; Vanden Heuvel, Elizabeth A. ; Lacke, Christine E. ; Spindel, Steven A. ; White, A. Clinton ; Hamill, Richard J. / Clinical prediction model for differentiation of disseminated Histoplasma capsulatum and Mycobacterium avium complex infections in febrile patients with AIDS. In: Journal of Acquired Immune Deficiency Syndromes. 2000 ; Vol. 24, No. 1. pp. 30-36.
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