TY - JOUR
T1 - Clinical profiles and outcomes of acute aortic dissection in a predominantly Hispanic population
AU - Alkhateeb, Haider
AU - Said, Sarmad
AU - Cooper, Chad J.
AU - Rodriguez-Castro, Carlos
AU - Dwivedi, Alok
AU - Onate, Eduardo
AU - Quansah, Raphael
AU - Mukherjee, Debabrata
PY - 2014/5/7
Y1 - 2014/5/7
N2 - Background: Acute aortic dissection (AAD) is a life-threatening cardiovascular condition with high morbidity and mortality. We sought to assess clinical profiles as well as outcomes of AAD in a predominantly Hispanic population and to explore the relationship between this condition and uncontrolled/untreated hypertension in this community. Material/Methods: This was a single-center, retrospective, cross-sectional study of patients admitted with AAD over a 10 years period. Results: Fifty-nine cases of AAD were included in the analysis. The group of Hispanics with AAD had more females (48.3%, p=0.002), more dyslipidemia and coronary artery disease (p=0.006 and 0.05, respectively), and a tendency to be older and have more hypertension and diabetes compared to non-Hispanics. Although 70.2% of all patients had hypertension, only 52.5% of them were being treated; of those, only 66.7% achieved optimal blood pressure control prior to presentation. Only 47.4% received beta-blockers for blood pressure control in the acute setting. Longer length of in-hospital stay was associated with older age, higher troponin and creatine kinase levels, and presence of hypertension. In-hospital death occurred in 10 (17%) patients and mortality was significantly associated with higher serum creatinine (p=0.01). Conclusions: Hispanic patients with AAD were more likely to be female, of older age, and have more cardiovascular risk factors in comparison to non-Hispanics. In addition, significant under-treatment of hypertension in this population and underutilization of beta-blockers for blood pressure control in the acute settings was evident. Better prevention and timely treatment may improve outcomes for this condition in this population.
AB - Background: Acute aortic dissection (AAD) is a life-threatening cardiovascular condition with high morbidity and mortality. We sought to assess clinical profiles as well as outcomes of AAD in a predominantly Hispanic population and to explore the relationship between this condition and uncontrolled/untreated hypertension in this community. Material/Methods: This was a single-center, retrospective, cross-sectional study of patients admitted with AAD over a 10 years period. Results: Fifty-nine cases of AAD were included in the analysis. The group of Hispanics with AAD had more females (48.3%, p=0.002), more dyslipidemia and coronary artery disease (p=0.006 and 0.05, respectively), and a tendency to be older and have more hypertension and diabetes compared to non-Hispanics. Although 70.2% of all patients had hypertension, only 52.5% of them were being treated; of those, only 66.7% achieved optimal blood pressure control prior to presentation. Only 47.4% received beta-blockers for blood pressure control in the acute setting. Longer length of in-hospital stay was associated with older age, higher troponin and creatine kinase levels, and presence of hypertension. In-hospital death occurred in 10 (17%) patients and mortality was significantly associated with higher serum creatinine (p=0.01). Conclusions: Hispanic patients with AAD were more likely to be female, of older age, and have more cardiovascular risk factors in comparison to non-Hispanics. In addition, significant under-treatment of hypertension in this population and underutilization of beta-blockers for blood pressure control in the acute settings was evident. Better prevention and timely treatment may improve outcomes for this condition in this population.
KW - Aortic diseases
KW - Blood pressure
KW - Dissection
KW - Hispanic Americans
UR - http://www.scopus.com/inward/record.url?scp=84900450709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84900450709&partnerID=8YFLogxK
U2 - 10.12659/MSM.890456
DO - 10.12659/MSM.890456
M3 - Article
C2 - 24800818
AN - SCOPUS:84900450709
SN - 1234-1010
VL - 20
SP - 747
EP - 751
JO - Medical Science Monitor
JF - Medical Science Monitor
ER -