Clinical spectrum of gram-positive infections in lung transplantation

M. R. Gupta, V. G. Valentine, J. E. Walker, G. A. Lombard, S. G. Laplace, L. Seoane, D. E. Taylor, G. S. Dhillon

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Gram-positive (GP) organisms are among the most common cause of infections in early postsurgical and immunocompromised populations. Patients recovering from lung transplantation (LT) are particularly susceptible owing to the physiologic stress imposed by surgery and induction with intense immunosuppression. Sites, types, and timing of GP infections following LT are not well documented. This report describes the clinical spectrum of GP infections and their effects on surgical airway complications (SAC) and bronchiolitis obliterans syndrome (BOS) following LT. Methods and materials. Data were collected from 202 patients undergoing 208 LT procedures at a single institution between November 1990 and November 2005. Data were retrospectively analyzed according to timing, location, and causative pathogen. Results. In the median follow-up period of 2.7 years (range, 0-13.6 years), 137 GP infections were confirmed in 72 patients. Sites of infection included respiratory tract (42%), blood (27%), skin, wound and catheter (21%), and other (10%). GP pathogens identified were Staphylococcus species (77%), Enterococcus species (12%), Streptococcus species (6%), Pneumococcus (4%), and Eubacterium lentum (1%). The likelihood of SAC and BOS was increased in lung allograft recipients with GP pneumonia as compared with those without (hazard ratio 2.1; 95% confidence interval=1.5-3.1). Conclusions. GP organisms were responsible for infections in 40% of lung allograft recipients and most commonly isolated from the respiratory tract and blood stream. Staphylococcal species were most frequently identified, 42% of which were methicillin-resistant Staphylococcus aureus (MRSA). Given the strong association of respiratory tract infections with the development of SAC and BOS, empiric antimicrobial strategies after LT should include agents directed against GP organisms, especially MRSA.

Original languageEnglish (US)
Pages (from-to)424-431
Number of pages8
JournalTransplant Infectious Disease
Volume11
Issue number5
DOIs
StatePublished - Oct 2009

Fingerprint

Lung Transplantation
Bronchiolitis Obliterans
Infection
Methicillin-Resistant Staphylococcus aureus
Respiratory Tract Infections
Allografts
Eubacterium
Lung
Enterococcus
Streptococcus pneumoniae
Streptococcus
Staphylococcus
Respiratory System
Immunosuppression
Pneumonia
Catheters
Confidence Intervals
Skin
Wounds and Injuries
Population

Keywords

  • Bronchiolitis obliterans syndrome
  • Gram-positive organisms
  • Infection
  • Lung transplant
  • Surgical airway complication

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

Gupta, M. R., Valentine, V. G., Walker, J. E., Lombard, G. A., Laplace, S. G., Seoane, L., ... Dhillon, G. S. (2009). Clinical spectrum of gram-positive infections in lung transplantation. Transplant Infectious Disease, 11(5), 424-431. https://doi.org/10.1111/j.1399-3062.2009.00422.x

Clinical spectrum of gram-positive infections in lung transplantation. / Gupta, M. R.; Valentine, V. G.; Walker, J. E.; Lombard, G. A.; Laplace, S. G.; Seoane, L.; Taylor, D. E.; Dhillon, G. S.

In: Transplant Infectious Disease, Vol. 11, No. 5, 10.2009, p. 424-431.

Research output: Contribution to journalArticle

Gupta, MR, Valentine, VG, Walker, JE, Lombard, GA, Laplace, SG, Seoane, L, Taylor, DE & Dhillon, GS 2009, 'Clinical spectrum of gram-positive infections in lung transplantation', Transplant Infectious Disease, vol. 11, no. 5, pp. 424-431. https://doi.org/10.1111/j.1399-3062.2009.00422.x
Gupta MR, Valentine VG, Walker JE, Lombard GA, Laplace SG, Seoane L et al. Clinical spectrum of gram-positive infections in lung transplantation. Transplant Infectious Disease. 2009 Oct;11(5):424-431. https://doi.org/10.1111/j.1399-3062.2009.00422.x
Gupta, M. R. ; Valentine, V. G. ; Walker, J. E. ; Lombard, G. A. ; Laplace, S. G. ; Seoane, L. ; Taylor, D. E. ; Dhillon, G. S. / Clinical spectrum of gram-positive infections in lung transplantation. In: Transplant Infectious Disease. 2009 ; Vol. 11, No. 5. pp. 424-431.
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abstract = "Gram-positive (GP) organisms are among the most common cause of infections in early postsurgical and immunocompromised populations. Patients recovering from lung transplantation (LT) are particularly susceptible owing to the physiologic stress imposed by surgery and induction with intense immunosuppression. Sites, types, and timing of GP infections following LT are not well documented. This report describes the clinical spectrum of GP infections and their effects on surgical airway complications (SAC) and bronchiolitis obliterans syndrome (BOS) following LT. Methods and materials. Data were collected from 202 patients undergoing 208 LT procedures at a single institution between November 1990 and November 2005. Data were retrospectively analyzed according to timing, location, and causative pathogen. Results. In the median follow-up period of 2.7 years (range, 0-13.6 years), 137 GP infections were confirmed in 72 patients. Sites of infection included respiratory tract (42{\%}), blood (27{\%}), skin, wound and catheter (21{\%}), and other (10{\%}). GP pathogens identified were Staphylococcus species (77{\%}), Enterococcus species (12{\%}), Streptococcus species (6{\%}), Pneumococcus (4{\%}), and Eubacterium lentum (1{\%}). The likelihood of SAC and BOS was increased in lung allograft recipients with GP pneumonia as compared with those without (hazard ratio 2.1; 95{\%} confidence interval=1.5-3.1). Conclusions. GP organisms were responsible for infections in 40{\%} of lung allograft recipients and most commonly isolated from the respiratory tract and blood stream. Staphylococcal species were most frequently identified, 42{\%} of which were methicillin-resistant Staphylococcus aureus (MRSA). Given the strong association of respiratory tract infections with the development of SAC and BOS, empiric antimicrobial strategies after LT should include agents directed against GP organisms, especially MRSA.",
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AB - Gram-positive (GP) organisms are among the most common cause of infections in early postsurgical and immunocompromised populations. Patients recovering from lung transplantation (LT) are particularly susceptible owing to the physiologic stress imposed by surgery and induction with intense immunosuppression. Sites, types, and timing of GP infections following LT are not well documented. This report describes the clinical spectrum of GP infections and their effects on surgical airway complications (SAC) and bronchiolitis obliterans syndrome (BOS) following LT. Methods and materials. Data were collected from 202 patients undergoing 208 LT procedures at a single institution between November 1990 and November 2005. Data were retrospectively analyzed according to timing, location, and causative pathogen. Results. In the median follow-up period of 2.7 years (range, 0-13.6 years), 137 GP infections were confirmed in 72 patients. Sites of infection included respiratory tract (42%), blood (27%), skin, wound and catheter (21%), and other (10%). GP pathogens identified were Staphylococcus species (77%), Enterococcus species (12%), Streptococcus species (6%), Pneumococcus (4%), and Eubacterium lentum (1%). The likelihood of SAC and BOS was increased in lung allograft recipients with GP pneumonia as compared with those without (hazard ratio 2.1; 95% confidence interval=1.5-3.1). Conclusions. GP organisms were responsible for infections in 40% of lung allograft recipients and most commonly isolated from the respiratory tract and blood stream. Staphylococcal species were most frequently identified, 42% of which were methicillin-resistant Staphylococcus aureus (MRSA). Given the strong association of respiratory tract infections with the development of SAC and BOS, empiric antimicrobial strategies after LT should include agents directed against GP organisms, especially MRSA.

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