Clinicocytopathologic correlation in an atypical presentation of lymphadenopathy with review of literature

Alexander H. Choi, Michael Bolaris, Diana Nguyen, Eduard H. Panosyan, Joseph L. Lasky, Gloria B. Duane

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Objectives: To present a clinicocytopathologic correlation of an atypical case of cat scratch disease (CSD) involving retroperitoneal lymph nodes, with emphasis on communication between service teams for managing lymphadenopathy of unknown origin. We consider clinical and cytologic differential diagnoses and review the literature on atypical cases of CSD, with emphasis on abdominal presentation and cytologic findings. Methods: Clinical services met with the cytology service to review clinical and pathologic features. Literature was reviewed via PubMed search (Harbor-UCLA subscriptions). Immunohistochemistry and Steiner silver stains were performed by Harbor-UCLA Department of Pathology. Enzyme-linked immunosorbent assay IgG and IgM Bartonella henselae titers were carried out by Quest Nichols Institute. Results: Fine-needle aspirate Diff-Quik and Papanicolaou smears and H&E-stained cell block showed abundant histiocytes, monocytoid B cells, and numerous neutrophils associated with necrosis corresponding to a late stage of CSD infection. Silver stain was positive for clumps of pleomorphic organisms. IgM and IgG antibody titers were elevated. Conclusions: The cytologic findings of CSD in an atypical abdominal presentation are similar to those of a classic presentation. Laboratory workup for atypical CSD should include at least two other modalities aside from cytomorphologic features. Close clinical and cytologic correlation avoided potentially unnecessary and harmful surgery and enabled timely treatment.

Original languageEnglish (US)
Pages (from-to)749-754
Number of pages6
JournalAmerican Journal of Clinical Pathology
Volume143
Issue number5
DOIs
StatePublished - May 1 2015
Externally publishedYes

Fingerprint

Cat-Scratch Disease
Silver
Immunoglobulin M
Coloring Agents
Immunoglobulin G
Bartonella henselae
Unnecessary Procedures
Papanicolaou Test
Histiocytes
PubMed
Needles
Cell Biology
Neutrophils
Differential Diagnosis
B-Lymphocytes
Necrosis
Lymph Nodes
Enzyme-Linked Immunosorbent Assay
Immunohistochemistry
Lymphadenopathy

Keywords

  • Abdominal lymphadenopathy/lymphadenitis
  • Atypical cat scratch disease
  • EUS-FNA cytology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Clinicocytopathologic correlation in an atypical presentation of lymphadenopathy with review of literature. / Choi, Alexander H.; Bolaris, Michael; Nguyen, Diana; Panosyan, Eduard H.; Lasky, Joseph L.; Duane, Gloria B.

In: American Journal of Clinical Pathology, Vol. 143, No. 5, 01.05.2015, p. 749-754.

Research output: Contribution to journalReview article

Choi, Alexander H. ; Bolaris, Michael ; Nguyen, Diana ; Panosyan, Eduard H. ; Lasky, Joseph L. ; Duane, Gloria B. / Clinicocytopathologic correlation in an atypical presentation of lymphadenopathy with review of literature. In: American Journal of Clinical Pathology. 2015 ; Vol. 143, No. 5. pp. 749-754.
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