Clinicopathologic analysis of ampullary neoplasms in 450 patients

Implications for surgical strategy and long-term prognosis

Jordan M. Winter, John L. Cameron, Kelly Olino, Joseph M. Herman, Mechteld C. de Jong, Ralph H. Hruban, Christopher L. Wolfgang, Frederic Eckhauser, Barish H. Edil, Michael A. Choti, Richard D. Schulick, Timothy M. Pawlik

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Background: Whether ampullary neoplasms are best surgically managed by pancreaticoduodenectomy versus local ampullectomy is controversial. We sought to examine the outcome of patients undergoing pancreaticoduodenectomy versus ampullectomy, as well as to identify factors predictive of lymph node metastasis in patients with ampullary neoplasms. Methods: Between 1970 and 2007, 450 patients who underwent surgical resection of ampullary adenoma or adenocarcinoma were identified from a prospective, single-institution database. Data on clinicopathologic factors, morbidity, mortality, and survival were analyzed. Results: The initial surgical procedure was pancreaticoduodenectomy in 96.7% patients and ampullectomy in 3.3%. Final diagnosis was invasive adenocarcinoma (77.1%) or adenoma (22.9%). Median tumor size was similar for adenomas associated with an adenocarcinoma (2.5 cm) versus adenomas without invasive cancer (2.9 cm; P = 0.71). Morbidity was comparable with pancreaticoduodenectomy (52.2%) versus ampullectomy (33.3%; P = 0.15), as was 30-day mortality (pancreaticoduodenectomy, 2.1% versus ampullectomy, 0%; P = 0.6). Metastatic disease to regional lymph nodes was present in 54.5% patients with adenocarcinoma. Factors associated with presence of lymph node metastasis included tumor size ≥1 cm (OR 2.1), poor histologic grade (OR 4.8), perineural invasion (OR 3.0), microscopic vessel invasion (OR 6.6), and depth of invasion > pT1 (OR 4.3; all P < 0.05). Specifically, risk of lymph node metastasis increased with T stage (T1, 28.0%; T2, 50.9%; T3, 71.7%; T4, 77.3%; P < 0.001). Conclusion: When surgery is indicated, radical resection is required for early invasive adenocarcinoma of the ampulla of Vater, as lymph node metastases are present in nearly 30% of patients with T1 disease. Pancreaticoduodenectomy should be the preferred approach for most ampullary neoplasms that require surgical resection.

Original languageEnglish (US)
Pages (from-to)379-387
Number of pages9
JournalJournal of Gastrointestinal Surgery
Volume14
Issue number2
DOIs
StatePublished - Feb 2010
Externally publishedYes

Fingerprint

Pancreaticoduodenectomy
Adenocarcinoma
Adenoma
Lymph Nodes
Neoplasm Metastasis
Neoplasms
Ampulla of Vater
Morbidity
Mortality
Databases
Survival

Keywords

  • Ampullary adenocarcinoma
  • Ampullary carcinoma
  • Ampullary neoplasia
  • Pancreaticoduodenectomy
  • Whipple

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology
  • Medicine(all)

Cite this

Winter, J. M., Cameron, J. L., Olino, K., Herman, J. M., de Jong, M. C., Hruban, R. H., ... Pawlik, T. M. (2010). Clinicopathologic analysis of ampullary neoplasms in 450 patients: Implications for surgical strategy and long-term prognosis. Journal of Gastrointestinal Surgery, 14(2), 379-387. https://doi.org/10.1007/s11605-009-1080-7

Clinicopathologic analysis of ampullary neoplasms in 450 patients : Implications for surgical strategy and long-term prognosis. / Winter, Jordan M.; Cameron, John L.; Olino, Kelly; Herman, Joseph M.; de Jong, Mechteld C.; Hruban, Ralph H.; Wolfgang, Christopher L.; Eckhauser, Frederic; Edil, Barish H.; Choti, Michael A.; Schulick, Richard D.; Pawlik, Timothy M.

In: Journal of Gastrointestinal Surgery, Vol. 14, No. 2, 02.2010, p. 379-387.

Research output: Contribution to journalArticle

Winter, JM, Cameron, JL, Olino, K, Herman, JM, de Jong, MC, Hruban, RH, Wolfgang, CL, Eckhauser, F, Edil, BH, Choti, MA, Schulick, RD & Pawlik, TM 2010, 'Clinicopathologic analysis of ampullary neoplasms in 450 patients: Implications for surgical strategy and long-term prognosis', Journal of Gastrointestinal Surgery, vol. 14, no. 2, pp. 379-387. https://doi.org/10.1007/s11605-009-1080-7
Winter, Jordan M. ; Cameron, John L. ; Olino, Kelly ; Herman, Joseph M. ; de Jong, Mechteld C. ; Hruban, Ralph H. ; Wolfgang, Christopher L. ; Eckhauser, Frederic ; Edil, Barish H. ; Choti, Michael A. ; Schulick, Richard D. ; Pawlik, Timothy M. / Clinicopathologic analysis of ampullary neoplasms in 450 patients : Implications for surgical strategy and long-term prognosis. In: Journal of Gastrointestinal Surgery. 2010 ; Vol. 14, No. 2. pp. 379-387.
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title = "Clinicopathologic analysis of ampullary neoplasms in 450 patients: Implications for surgical strategy and long-term prognosis",
abstract = "Background: Whether ampullary neoplasms are best surgically managed by pancreaticoduodenectomy versus local ampullectomy is controversial. We sought to examine the outcome of patients undergoing pancreaticoduodenectomy versus ampullectomy, as well as to identify factors predictive of lymph node metastasis in patients with ampullary neoplasms. Methods: Between 1970 and 2007, 450 patients who underwent surgical resection of ampullary adenoma or adenocarcinoma were identified from a prospective, single-institution database. Data on clinicopathologic factors, morbidity, mortality, and survival were analyzed. Results: The initial surgical procedure was pancreaticoduodenectomy in 96.7{\%} patients and ampullectomy in 3.3{\%}. Final diagnosis was invasive adenocarcinoma (77.1{\%}) or adenoma (22.9{\%}). Median tumor size was similar for adenomas associated with an adenocarcinoma (2.5 cm) versus adenomas without invasive cancer (2.9 cm; P = 0.71). Morbidity was comparable with pancreaticoduodenectomy (52.2{\%}) versus ampullectomy (33.3{\%}; P = 0.15), as was 30-day mortality (pancreaticoduodenectomy, 2.1{\%} versus ampullectomy, 0{\%}; P = 0.6). Metastatic disease to regional lymph nodes was present in 54.5{\%} patients with adenocarcinoma. Factors associated with presence of lymph node metastasis included tumor size ≥1 cm (OR 2.1), poor histologic grade (OR 4.8), perineural invasion (OR 3.0), microscopic vessel invasion (OR 6.6), and depth of invasion > pT1 (OR 4.3; all P < 0.05). Specifically, risk of lymph node metastasis increased with T stage (T1, 28.0{\%}; T2, 50.9{\%}; T3, 71.7{\%}; T4, 77.3{\%}; P < 0.001). Conclusion: When surgery is indicated, radical resection is required for early invasive adenocarcinoma of the ampulla of Vater, as lymph node metastases are present in nearly 30{\%} of patients with T1 disease. Pancreaticoduodenectomy should be the preferred approach for most ampullary neoplasms that require surgical resection.",
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author = "Winter, {Jordan M.} and Cameron, {John L.} and Kelly Olino and Herman, {Joseph M.} and {de Jong}, {Mechteld C.} and Hruban, {Ralph H.} and Wolfgang, {Christopher L.} and Frederic Eckhauser and Edil, {Barish H.} and Choti, {Michael A.} and Schulick, {Richard D.} and Pawlik, {Timothy M.}",
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T2 - Implications for surgical strategy and long-term prognosis

AU - Winter, Jordan M.

AU - Cameron, John L.

AU - Olino, Kelly

AU - Herman, Joseph M.

AU - de Jong, Mechteld C.

AU - Hruban, Ralph H.

AU - Wolfgang, Christopher L.

AU - Eckhauser, Frederic

AU - Edil, Barish H.

AU - Choti, Michael A.

AU - Schulick, Richard D.

AU - Pawlik, Timothy M.

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N2 - Background: Whether ampullary neoplasms are best surgically managed by pancreaticoduodenectomy versus local ampullectomy is controversial. We sought to examine the outcome of patients undergoing pancreaticoduodenectomy versus ampullectomy, as well as to identify factors predictive of lymph node metastasis in patients with ampullary neoplasms. Methods: Between 1970 and 2007, 450 patients who underwent surgical resection of ampullary adenoma or adenocarcinoma were identified from a prospective, single-institution database. Data on clinicopathologic factors, morbidity, mortality, and survival were analyzed. Results: The initial surgical procedure was pancreaticoduodenectomy in 96.7% patients and ampullectomy in 3.3%. Final diagnosis was invasive adenocarcinoma (77.1%) or adenoma (22.9%). Median tumor size was similar for adenomas associated with an adenocarcinoma (2.5 cm) versus adenomas without invasive cancer (2.9 cm; P = 0.71). Morbidity was comparable with pancreaticoduodenectomy (52.2%) versus ampullectomy (33.3%; P = 0.15), as was 30-day mortality (pancreaticoduodenectomy, 2.1% versus ampullectomy, 0%; P = 0.6). Metastatic disease to regional lymph nodes was present in 54.5% patients with adenocarcinoma. Factors associated with presence of lymph node metastasis included tumor size ≥1 cm (OR 2.1), poor histologic grade (OR 4.8), perineural invasion (OR 3.0), microscopic vessel invasion (OR 6.6), and depth of invasion > pT1 (OR 4.3; all P < 0.05). Specifically, risk of lymph node metastasis increased with T stage (T1, 28.0%; T2, 50.9%; T3, 71.7%; T4, 77.3%; P < 0.001). Conclusion: When surgery is indicated, radical resection is required for early invasive adenocarcinoma of the ampulla of Vater, as lymph node metastases are present in nearly 30% of patients with T1 disease. Pancreaticoduodenectomy should be the preferred approach for most ampullary neoplasms that require surgical resection.

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KW - Pancreaticoduodenectomy

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