The cDNAs encoding the enhancer of split groucho (ESG) and its related amino-terminal (AES) proteins were isolated and sequenced from human, mouse, alligator, Xenopus and nematode. The ESG proteins consist of 771 amino acids, while the AES proteins contain 197 amino acids. The AES proteins were found to exhibit approximately 50% identity to the amino-terminal region of Drosophila enhancer of split groucho protein. The expression of ESG and AES transcripts have been investigated from various tissues and/or developmental stages of human, mouse and Xenopus. The evolutionary relationships among these AES and ESG genes were analyzed. These AES proteins from Xenopus, Alligator, mouse, rat and human are clustered into a group, while the ESG proteins from nematode, Drosophila, Xenopus, mouse, rat and human are clustered into a separate group.
|Original language||English (US)|
|State||Published - Dec 1 1996|
ASJC Scopus subject areas
- Molecular Biology