ABSTRACT: Pulmonary injury can be characterized by an increased need for FiO2 to maintain SaO2. We tested a smart oxygenation system (SOS) that utilizes the activity of a closed-loop control FiO2 algorithm (CLC-FiO2) to rapidly assess acute respiratory distress syndrome (ARDS) severity so that rescue ventilation (RscVent) can be initiated earlier. After baseline data, a pulse-oximeter (SpO2) was placed. Sheep were then subjected to burn and smoke inhalation injury and followed for 48 hr. Initially, sheep were spontaneously ventilating and then randomized to: standard of care (SOC) (n?=?6), in which RscVent began when PaO2 ?250 occurred in 4/7, SOS and 0/7, SOC. At 48 hr the SpO2/FiO2 ratio was 104?±?5 SOC versus 228?±?59 SOS, p?=?0.036. Ventilatory compliance and peak airway pressures were significantly improved with SOS vs SOC (p?
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
- Emergency Medicine