Closed-loop Control of FiO2 Rapidly Identifies Need for Rescue Ventilation and Reduces ARDS Severity in a Conscious Sheep Model of Burn and Smoke Inhalation Injury

Nehemiah T. Liu, Michael G. Salter, Muzna Khan, Richard D. Branson, Perenlei Enkhbaatar, George Kramer, José Salinas, Nicole Riberio Marques, Michael Kinsky

Research output: Contribution to journalArticle

4 Scopus citations


ABSTRACT: Pulmonary injury can be characterized by an increased need for FiO2 to maintain SaO2. We tested a smart oxygenation system (SOS) that utilizes the activity of a closed-loop control FiO2 algorithm (CLC-FiO2) to rapidly assess acute respiratory distress syndrome (ARDS) severity so that rescue ventilation (RscVent) can be initiated earlier. After baseline data, a pulse-oximeter (SpO2) was placed. Sheep were then subjected to burn and smoke inhalation injury and followed for 48 hr. Initially, sheep were spontaneously ventilating and then randomized to: standard of care (SOC) (n?=?6), in which RscVent began when PaO2 ?250 occurred in 4/7, SOS and 0/7, SOC. At 48 hr the SpO2/FiO2 ratio was 104?±?5 SOC versus 228?±?59 SOS, p?=?0.036. Ventilatory compliance and peak airway pressures were significantly improved with SOS vs SOC (p?

Original languageEnglish (US)
StateAccepted/In press - Jul 7 2016


ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine

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