TY - JOUR
T1 - Closed-loop Control of FiO2 Rapidly Identifies Need for Rescue Ventilation and Reduces ARDS Severity in a Conscious Sheep Model of Burn and Smoke Inhalation Injury
AU - Liu, Nehemiah T.
AU - Salter, Michael G.
AU - Khan, Muzna
AU - Branson, Richard D.
AU - Enkhbaatar, Perenlei
AU - Kramer, George
AU - Salinas, José
AU - Marques, Nicole Riberio
AU - Kinsky, Michael
PY - 2016/7/7
Y1 - 2016/7/7
N2 - ABSTRACT: Pulmonary injury can be characterized by an increased need for FiO2 to maintain SaO2. We tested a smart oxygenation system (SOS) that utilizes the activity of a closed-loop control FiO2 algorithm (CLC-FiO2) to rapidly assess acute respiratory distress syndrome (ARDS) severity so that rescue ventilation (RscVent) can be initiated earlier. After baseline data, a pulse-oximeter (SpO2) was placed. Sheep were then subjected to burn and smoke inhalation injury and followed for 48 hr. Initially, sheep were spontaneously ventilating and then randomized to: standard of care (SOC) (n?=?6), in which RscVent began when PaO2 ?250 occurred in 4/7, SOS and 0/7, SOC. At 48 hr the SpO2/FiO2 ratio was 104?±?5 SOC versus 228?±?59 SOS, p?=?0.036. Ventilatory compliance and peak airway pressures were significantly improved with SOS vs SOC (p?
AB - ABSTRACT: Pulmonary injury can be characterized by an increased need for FiO2 to maintain SaO2. We tested a smart oxygenation system (SOS) that utilizes the activity of a closed-loop control FiO2 algorithm (CLC-FiO2) to rapidly assess acute respiratory distress syndrome (ARDS) severity so that rescue ventilation (RscVent) can be initiated earlier. After baseline data, a pulse-oximeter (SpO2) was placed. Sheep were then subjected to burn and smoke inhalation injury and followed for 48 hr. Initially, sheep were spontaneously ventilating and then randomized to: standard of care (SOC) (n?=?6), in which RscVent began when PaO2 ?250 occurred in 4/7, SOS and 0/7, SOC. At 48 hr the SpO2/FiO2 ratio was 104?±?5 SOC versus 228?±?59 SOS, p?=?0.036. Ventilatory compliance and peak airway pressures were significantly improved with SOS vs SOC (p?
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U2 - 10.1097/SHK.0000000000000686
DO - 10.1097/SHK.0000000000000686
M3 - Article
C2 - 27392155
AN - SCOPUS:84978153874
SN - 1073-2322
JO - Shock
JF - Shock
ER -