Co-Infection with TB and HIV: Converging epidemics, clinical challenges, and microbial synergy

Matthew B. Huante, Rebecca J. Nusbaum, Janice J. Endsley

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations


Human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb) are the two leading causes of infectious disease-related death today. An estimated 2.6 million people die as a result of infection with one or both of these pathogens annually, while a range of morbidities afflict tens of millions more. The resurgence of TB in the years following the start of the HIV/AIDS pandemic revealed a close relationship of these two infectious diseases. TB and HIV are now viewed as a syndemic that impedes efforts to reduce incidence of infection, complicates treatment, and promotes development of drug resistance. This chapter summarizes the complex factors whereby TB and HIV converge to drive a global health emergency and discusses ongoing research and clinical efforts to reduce dual disease.

Original languageEnglish (US)
Title of host publicationTuberculosis Host-Pathogen Interactions
PublisherSpringer International Publishing
Number of pages31
ISBN (Electronic)9783030253813
ISBN (Print)9783030253806
StatePublished - Sep 10 2019


  • Cellular immunity
  • Clinical challenges
  • Drug resistance
  • Immune dysfunction
  • Innate immunity
  • Microbial synergy
  • Pathogenesis
  • TB and HIV co-infection
  • Tuberculosis

ASJC Scopus subject areas

  • General Medicine
  • General Immunology and Microbiology


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