Co-Infection with TB and HIV: Converging epidemics, clinical challenges, and microbial synergy

Matthew B. Huante; Rebecca J. Nusbaum; Janice J. Endsley

doi:10.1007/978-3-030-25381-3_7

Co-Infection with TB and HIV: Converging epidemics, clinical challenges, and microbial synergy

Matthew B. Huante, Rebecca J. Nusbaum, Janice J. Endsley

Microbiology And Immunology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

8 Scopus citations

Abstract

Human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb) are the two leading causes of infectious disease-related death today. An estimated 2.6 million people die as a result of infection with one or both of these pathogens annually, while a range of morbidities afflict tens of millions more. The resurgence of TB in the years following the start of the HIV/AIDS pandemic revealed a close relationship of these two infectious diseases. TB and HIV are now viewed as a syndemic that impedes efforts to reduce incidence of infection, complicates treatment, and promotes development of drug resistance. This chapter summarizes the complex factors whereby TB and HIV converge to drive a global health emergency and discusses ongoing research and clinical efforts to reduce dual disease.

Original language	English (US)
Title of host publication	Tuberculosis Host-Pathogen Interactions
Publisher	Springer International Publishing
Pages	123-153
Number of pages	31
ISBN (Electronic)	9783030253813
ISBN (Print)	9783030253806
DOIs	https://doi.org/10.1007/978-3-030-25381-3_7
State	Published - Sep 10 2019

Keywords

Cellular immunity
Clinical challenges
Drug resistance
HIV/AIDS
Immune dysfunction
Innate immunity
Microbial synergy
Pathogenesis
TB and HIV co-infection
Tuberculosis

ASJC Scopus subject areas

General Medicine
General Immunology and Microbiology

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10.1007/978-3-030-25381-3_7

Cite this

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abstract = "Human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb) are the two leading causes of infectious disease-related death today. An estimated 2.6 million people die as a result of infection with one or both of these pathogens annually, while a range of morbidities afflict tens of millions more. The resurgence of TB in the years following the start of the HIV/AIDS pandemic revealed a close relationship of these two infectious diseases. TB and HIV are now viewed as a syndemic that impedes efforts to reduce incidence of infection, complicates treatment, and promotes development of drug resistance. This chapter summarizes the complex factors whereby TB and HIV converge to drive a global health emergency and discusses ongoing research and clinical efforts to reduce dual disease.",

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AU - Endsley, Janice J.

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KW - Clinical challenges

KW - Drug resistance

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KW - Immune dysfunction

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Co-Infection with TB and HIV: Converging epidemics, clinical challenges, and microbial synergy

Abstract

Keywords

ASJC Scopus subject areas

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