Co-infections with hepatitis B and C viruses in human immunodeficiency virus-infected patients in Morocco

K. Rebbani; A. Ouladlahsen; A. Bensghir; A. Akil; H. Lamdini; H. Issouf; I. Brahim; B. Kitab; F. Z. Fakhir; L. Wakrim; K. Marhoum El Filali; H. Himmich; S. Ezzikouri; S. Benjelloun

doi:10.1111/1469-0691.12252

Co-infections with hepatitis B and C viruses in human immunodeficiency virus-infected patients in Morocco

K. Rebbani, A. Ouladlahsen, A. Bensghir, A. Akil, H. Lamdini, H. Issouf, I. Brahim, B. Kitab, F. Z. Fakhir, L. Wakrim, K. Marhoum El Filali, H. Himmich, S. Ezzikouri, S. Benjelloun

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are major public health concerns. We aimed to determine the prevalence of HBV and HCV infections among HIV-infected patients, and to identify the main circulating hepatitis strains in Morocco. The study was carried out in 503 HIV-infected patients. Our survey indicated that the prevalence of HIV/hepatitis co-infection was 10.6%; 5.2% of patients were HBV surface antigen positive, and 5.4% of patients were anti-HCV positive. Among the HBV surface antigen-positive group, HBV DNA sequencing identified exclusively genotype D (D1: 26.7%; D7: 73.3%) in accordance with what is found in the general population. In contrast, sequencing of HCV isolates produced an unusual subtype distribution with a decreasing order of prevalence: 1a, 3a (both 23.5%), 1b, 4a (both 17.6%), 1c (11.8%) and 6h (6%).

Original language	English (US)
Pages (from-to)	E454-E457
Journal	Clinical Microbiology and Infection
Volume	19
Issue number	10
DOIs	https://doi.org/10.1111/1469-0691.12252
State	Published - Oct 2013
Externally published	Yes

Keywords

Chronic hepatitis
Co-infection
Genotype
Human immunodeficiency virus
Prevalence

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1111/1469-0691.12252

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Rebbani, K., Ouladlahsen, A., Bensghir, A., Akil, A., Lamdini, H., Issouf, H., Brahim, I., Kitab, B., Fakhir, F. Z., Wakrim, L., Marhoum El Filali, K., Himmich, H., Ezzikouri, S., & Benjelloun, S. (2013). Co-infections with hepatitis B and C viruses in human immunodeficiency virus-infected patients in Morocco. Clinical Microbiology and Infection, 19(10), E454-E457. https://doi.org/10.1111/1469-0691.12252

Rebbani, K, Ouladlahsen, A, Bensghir, A, Akil, A, Lamdini, H, Issouf, H, Brahim, I, Kitab, B, Fakhir, FZ, Wakrim, L, Marhoum El Filali, K, Himmich, H, Ezzikouri, S & Benjelloun, S 2013, 'Co-infections with hepatitis B and C viruses in human immunodeficiency virus-infected patients in Morocco', Clinical Microbiology and Infection, vol. 19, no. 10, pp. E454-E457. https://doi.org/10.1111/1469-0691.12252

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title = "Co-infections with hepatitis B and C viruses in human immunodeficiency virus-infected patients in Morocco",

abstract = "Human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are major public health concerns. We aimed to determine the prevalence of HBV and HCV infections among HIV-infected patients, and to identify the main circulating hepatitis strains in Morocco. The study was carried out in 503 HIV-infected patients. Our survey indicated that the prevalence of HIV/hepatitis co-infection was 10.6%; 5.2% of patients were HBV surface antigen positive, and 5.4% of patients were anti-HCV positive. Among the HBV surface antigen-positive group, HBV DNA sequencing identified exclusively genotype D (D1: 26.7%; D7: 73.3%) in accordance with what is found in the general population. In contrast, sequencing of HCV isolates produced an unusual subtype distribution with a decreasing order of prevalence: 1a, 3a (both 23.5%), 1b, 4a (both 17.6%), 1c (11.8%) and 6h (6%).",

keywords = "Chronic hepatitis, Co-infection, Genotype, Human immunodeficiency virus, Prevalence",

author = "K. Rebbani and A. Ouladlahsen and A. Bensghir and A. Akil and H. Lamdini and H. Issouf and I. Brahim and B. Kitab and Fakhir, {F. Z.} and L. Wakrim and {Marhoum El Filali}, K. and H. Himmich and S. Ezzikouri and S. Benjelloun",

note = "Funding Information: The authors would like to acknowledge all patients for their participation in this study and the Association de lutte contre le SIDA (ALCS). We are particularly grateful to Prof. Christian Trepo for useful review of the manuscript, to Dr Pascal Pineau for advice, rich commentary and critical reading of the manuscript, and to Prof. George Y. Wu for pertinent English revision of the manuscript. This work was supported by The Fonds d'Appui Structure Partenaire (FASP). ",

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doi = "10.1111/1469-0691.12252",

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AU - Rebbani, K.

AU - Ouladlahsen, A.

AU - Bensghir, A.

AU - Akil, A.

AU - Lamdini, H.

AU - Issouf, H.

AU - Brahim, I.

AU - Kitab, B.

AU - Fakhir, F. Z.

AU - Wakrim, L.

AU - Marhoum El Filali, K.

AU - Himmich, H.

AU - Ezzikouri, S.

AU - Benjelloun, S.

N1 - Funding Information: The authors would like to acknowledge all patients for their participation in this study and the Association de lutte contre le SIDA (ALCS). We are particularly grateful to Prof. Christian Trepo for useful review of the manuscript, to Dr Pascal Pineau for advice, rich commentary and critical reading of the manuscript, and to Prof. George Y. Wu for pertinent English revision of the manuscript. This work was supported by The Fonds d'Appui Structure Partenaire (FASP).

PY - 2013/10

Y1 - 2013/10

N2 - Human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are major public health concerns. We aimed to determine the prevalence of HBV and HCV infections among HIV-infected patients, and to identify the main circulating hepatitis strains in Morocco. The study was carried out in 503 HIV-infected patients. Our survey indicated that the prevalence of HIV/hepatitis co-infection was 10.6%; 5.2% of patients were HBV surface antigen positive, and 5.4% of patients were anti-HCV positive. Among the HBV surface antigen-positive group, HBV DNA sequencing identified exclusively genotype D (D1: 26.7%; D7: 73.3%) in accordance with what is found in the general population. In contrast, sequencing of HCV isolates produced an unusual subtype distribution with a decreasing order of prevalence: 1a, 3a (both 23.5%), 1b, 4a (both 17.6%), 1c (11.8%) and 6h (6%).

AB - Human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are major public health concerns. We aimed to determine the prevalence of HBV and HCV infections among HIV-infected patients, and to identify the main circulating hepatitis strains in Morocco. The study was carried out in 503 HIV-infected patients. Our survey indicated that the prevalence of HIV/hepatitis co-infection was 10.6%; 5.2% of patients were HBV surface antigen positive, and 5.4% of patients were anti-HCV positive. Among the HBV surface antigen-positive group, HBV DNA sequencing identified exclusively genotype D (D1: 26.7%; D7: 73.3%) in accordance with what is found in the general population. In contrast, sequencing of HCV isolates produced an unusual subtype distribution with a decreasing order of prevalence: 1a, 3a (both 23.5%), 1b, 4a (both 17.6%), 1c (11.8%) and 6h (6%).

KW - Chronic hepatitis

KW - Co-infection

KW - Genotype

KW - Human immunodeficiency virus

KW - Prevalence

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Co-infections with hepatitis B and C viruses in human immunodeficiency virus-infected patients in Morocco

Abstract

Keywords

ASJC Scopus subject areas

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