Abstract
Autoimmune mechanisms are implicated in both myasthenia gravis (MG) and multiple sclerosis (MS), and hypothesis of a common immunological mechanism of pathogenesis is supported by the fact that this rare combination of the two diseases occurs more frequently than expected by random association. Although MS is primarily mediated by T lymphocytes and MG primarily involves the destruction of the neuromuscular junction by antibodies, there are evidences that support both cell-mediated and humoral immunity are involved in the pathogenesis of both diseases. Different studies have shown dysfunction of T cells as well as B cells involved in the pathogenesis of both disorders. Previous case reports, mainly present female patients who had a mild presentation of MG, either prior or after diagnosis of MS. In this article, in addition to presenting a unique male patient with a previous diagnosis of MS, who presented with MG crisis, we aimed to review the literature to find the common immunological mechanisms involved in the pathogenesis of MG and MS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 135-136 |
| Number of pages | 2 |
| Journal | Multiple Sclerosis and Related Disorders |
| Volume | 34 |
| DOIs | |
| State | Published - Sep 1 2019 |
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Keywords
- Autoimmune diseases
- Multiple sclerosis
- Myasthenia gravis
- Neuroimmunology
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Co-occurrence of multiple sclerosis and myasthenia gravis : A case report and review of immunological theories. / Dehbashi, Sara; Hamouda, Diaa; Shanina, Elena.
In: Multiple Sclerosis and Related Disorders, Vol. 34, 01.09.2019, p. 135-136.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Co-occurrence of multiple sclerosis and myasthenia gravis
T2 - A case report and review of immunological theories
AU - Dehbashi, Sara
AU - Hamouda, Diaa
AU - Shanina, Elena
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Autoimmune mechanisms are implicated in both myasthenia gravis (MG) and multiple sclerosis (MS), and hypothesis of a common immunological mechanism of pathogenesis is supported by the fact that this rare combination of the two diseases occurs more frequently than expected by random association. Although MS is primarily mediated by T lymphocytes and MG primarily involves the destruction of the neuromuscular junction by antibodies, there are evidences that support both cell-mediated and humoral immunity are involved in the pathogenesis of both diseases. Different studies have shown dysfunction of T cells as well as B cells involved in the pathogenesis of both disorders. Previous case reports, mainly present female patients who had a mild presentation of MG, either prior or after diagnosis of MS. In this article, in addition to presenting a unique male patient with a previous diagnosis of MS, who presented with MG crisis, we aimed to review the literature to find the common immunological mechanisms involved in the pathogenesis of MG and MS.
AB - Autoimmune mechanisms are implicated in both myasthenia gravis (MG) and multiple sclerosis (MS), and hypothesis of a common immunological mechanism of pathogenesis is supported by the fact that this rare combination of the two diseases occurs more frequently than expected by random association. Although MS is primarily mediated by T lymphocytes and MG primarily involves the destruction of the neuromuscular junction by antibodies, there are evidences that support both cell-mediated and humoral immunity are involved in the pathogenesis of both diseases. Different studies have shown dysfunction of T cells as well as B cells involved in the pathogenesis of both disorders. Previous case reports, mainly present female patients who had a mild presentation of MG, either prior or after diagnosis of MS. In this article, in addition to presenting a unique male patient with a previous diagnosis of MS, who presented with MG crisis, we aimed to review the literature to find the common immunological mechanisms involved in the pathogenesis of MG and MS.
KW - Autoimmune diseases
KW - Multiple sclerosis
KW - Myasthenia gravis
KW - Neuroimmunology
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U2 - 10.1016/j.msard.2019.06.027
DO - 10.1016/j.msard.2019.06.027
M3 - Article
VL - 34
SP - 135
EP - 136
JO - Multiple Sclerosis and Related Disorders
JF - Multiple Sclerosis and Related Disorders
SN - 2211-0348
ER -