Coagulation and wound repair during COVID-19

Vineet D. Menachery, Lisa E. Gralinski

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

While COVID-19 is best known as a respiratory infection, SARS-CoV-2 causes systemic disease manifestations including coagulopathies. Both dysregulated extracellular matrix remodeling pathways and circulating coagulation proteins are hallmarks of severe COVID-19 and often continue after the resolution of acute infection. Coagulation proteins have proven effective as biomarkers for severe disease and anticoagulants are a mainstay of COVID-19 therapeutics in hospitalized patients. While much knowledge has been gained about the role of clotting pathway activation in COVID-19, much remains to be elucidated in this complex network of signaling pathways.

Original languageEnglish (US)
Pages (from-to)1076-1081
Number of pages6
JournalJournal of Heart and Lung Transplantation
Volume40
Issue number10
DOIs
StatePublished - Oct 2021

Keywords

  • COVID-19
  • SARS-CoV-2
  • coagulation
  • coronavirus
  • fibrinolysis

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

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