Coagulopathy caused by vitamin K deficiency in critically ill, hospitalized patients

J. B. Alperin

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

A coagulopathy due to vitamin K deficiency was discovered in 42 hospitalized patients, most of whom had been misdiagnosed as having disseminated intravascular coagulation. Factors contributing to vitamin deficiency included inadequate diet, malabsorption, failure of physicians to prescribe vitamin K supplements, antibiotic therapy, renal insufficiency, hepatic dysfunction, recent major surgery, and possibly pregnancy. Sixteen patients (34%) bled sufficiently to need red blood cell transfusions and ten patients (24%) ultimately died. Of 18 patients who also had thrombocytopenia, three did have disseminated intravascular coagulation. The deficiency, a contributor to morbidity and mortality, can be prevented by prophylactic administration of vitamin K to severely ill patients who are eating inadequately and receiving antibiotics.

Original languageEnglish (US)
Pages (from-to)1916-1919
Number of pages4
JournalJournal of the American Medical Association
Volume258
Issue number14
StatePublished - 1987

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Vitamin K Deficiency
Critical Illness
Vitamin K
Disseminated Intravascular Coagulation
Anti-Bacterial Agents
Avitaminosis
Erythrocyte Transfusion
Diagnostic Errors
Thrombocytopenia
Renal Insufficiency
Eating
Diet
Morbidity
Physicians
Pregnancy
Mortality
Liver

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Coagulopathy caused by vitamin K deficiency in critically ill, hospitalized patients. / Alperin, J. B.

In: Journal of the American Medical Association, Vol. 258, No. 14, 1987, p. 1916-1919.

Research output: Contribution to journalArticle

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