Cocaine-induced behavioral sensitization is not associated with loss of GABA-immunoreactive neurons in the amygdala

Michael A. Lee; Joseph M. Paris; Kathryn A. Cunningham

doi:10.1016/0006-8993(91)91313-P

Cocaine-induced behavioral sensitization is not associated with loss of GABA-immunoreactive neurons in the amygdala

Michael A. Lee, Joseph M. Paris, Kathryn A. Cunningham

Pharmacology & Toxicology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We investigated whether cocaine-induced behavioral sensitization (15 mg/kg, twice daily for 7 days) is associated with changes in γ-aminobutyric acid (GABA) neurons in the lateral-basolateral amygdala of male Sprague-Dawley rats. The number of GABA-immunoreactive neurons in the amygdala did not differ between cocaine- and saline-treated rats. Although some aspects of this behavioral phenomenon parallel the kindling model of epilepsy, limbic alternations in GABA neurons do not appear to be associated with behavioral sensitization to cocaine.

Original language	English (US)
Pages (from-to)	351-354
Number of pages	4
Journal	Brain Research
Volume	545
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(91)91313-P
State	Published - Apr 5 1991

Keywords

Amygdala, Sensitization
Cocaine
Rat
γ-Aminobutyric acid

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(91)91313-P

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abstract = "We investigated whether cocaine-induced behavioral sensitization (15 mg/kg, twice daily for 7 days) is associated with changes in γ-aminobutyric acid (GABA) neurons in the lateral-basolateral amygdala of male Sprague-Dawley rats. The number of GABA-immunoreactive neurons in the amygdala did not differ between cocaine- and saline-treated rats. Although some aspects of this behavioral phenomenon parallel the kindling model of epilepsy, limbic alternations in GABA neurons do not appear to be associated with behavioral sensitization to cocaine.",

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AU - Paris, Joseph M.

AU - Cunningham, Kathryn A.

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N2 - We investigated whether cocaine-induced behavioral sensitization (15 mg/kg, twice daily for 7 days) is associated with changes in γ-aminobutyric acid (GABA) neurons in the lateral-basolateral amygdala of male Sprague-Dawley rats. The number of GABA-immunoreactive neurons in the amygdala did not differ between cocaine- and saline-treated rats. Although some aspects of this behavioral phenomenon parallel the kindling model of epilepsy, limbic alternations in GABA neurons do not appear to be associated with behavioral sensitization to cocaine.

AB - We investigated whether cocaine-induced behavioral sensitization (15 mg/kg, twice daily for 7 days) is associated with changes in γ-aminobutyric acid (GABA) neurons in the lateral-basolateral amygdala of male Sprague-Dawley rats. The number of GABA-immunoreactive neurons in the amygdala did not differ between cocaine- and saline-treated rats. Although some aspects of this behavioral phenomenon parallel the kindling model of epilepsy, limbic alternations in GABA neurons do not appear to be associated with behavioral sensitization to cocaine.

KW - Amygdala, Sensitization

KW - Cocaine

KW - Rat

KW - γ-Aminobutyric acid

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Cocaine-induced behavioral sensitization is not associated with loss of GABA-immunoreactive neurons in the amygdala

Abstract

Keywords

ASJC Scopus subject areas

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