Cocaine-induced behavioral sensitization is not associated with loss of GABA-immunoreactive neurons in the amygdala

Michael A. Lee, Joseph M. Paris, Kathryn A. Cunningham

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We investigated whether cocaine-induced behavioral sensitization (15 mg/kg, twice daily for 7 days) is associated with changes in γ-aminobutyric acid (GABA) neurons in the lateral-basolateral amygdala of male Sprague-Dawley rats. The number of GABA-immunoreactive neurons in the amygdala did not differ between cocaine- and saline-treated rats. Although some aspects of this behavioral phenomenon parallel the kindling model of epilepsy, limbic alternations in GABA neurons do not appear to be associated with behavioral sensitization to cocaine.

Original languageEnglish (US)
Pages (from-to)351-354
Number of pages4
JournalBrain Research
Volume545
Issue number1-2
DOIs
StatePublished - Apr 5 1991

Keywords

  • Amygdala, Sensitization
  • Cocaine
  • Rat
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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