Cogan's syndrome

E. William St. Clair, Rex M. McCallum

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Work originating in the 1940s led to the characterization of a rare, chronic inflammatory disorder with a unique predilection for the cornea and vestibuloauditory apparatus, now called Cogan's syndrome (CS) after the ophthalmologist who first described it. CS occurs primarily in young adults and typically presents with interstitial keratitis (IK) and Meniere's-like episodes developing within several months of each other. The inflammatory process may target other ocular sites, and the disease itself may be accompanied by aortitis or a Takayasu's-like or medium-sized vessel vasculitis. Morbidity in CS results from deafness and complications from cardiovascular disease. Most evidence suggests that the ocular and vestibuloauditory manifestations are not a consequence of vasculitis but rather mediated by other immunologic mechanisms, possibly organ-specific autoimmunity. The cornerstone of treatment in CS is corticosteroids, topically for IK and systemically for inner ear dysfunction. Early corticosteroid therapy appears to be critical for reversing hearing loss. Cochlear implants can partially restore auditory function and have been a salvation for patients who suffer from deafness as a result of permanent cochlear damage.

Original languageEnglish (US)
Pages (from-to)47-52
Number of pages6
JournalCurrent Opinion in Rheumatology
Volume11
Issue number1
DOIs
StatePublished - Jan 1999
Externally publishedYes

Fingerprint

Cogan Syndrome
Keratitis
Deafness
Vasculitis
Adrenal Cortex Hormones
Eye Manifestations
Aortitis
Cochlear Implants
Eye Diseases
Cochlea
Inner Ear
Secondary Prevention
Autoimmunity
Hearing Loss
Cornea
Young Adult
Cardiovascular Diseases
Morbidity

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Cogan's syndrome. / St. Clair, E. William; McCallum, Rex M.

In: Current Opinion in Rheumatology, Vol. 11, No. 1, 01.1999, p. 47-52.

Research output: Contribution to journalArticle

St. Clair, E. William ; McCallum, Rex M. / Cogan's syndrome. In: Current Opinion in Rheumatology. 1999 ; Vol. 11, No. 1. pp. 47-52.
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