Cogan's Syndrome

Rex M. McCallum, E. William St. Clair

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Cogan's syndrome (CS) is characterized by interstitial keratitis, which rarely produces blindness, and recurrent Meniere's-like vestibulo-auditory events with frequent progression to hearing loss and deafness. It is a rare disease with a mean age of onset at 29 years. The mortality rate is unknown. Approximately half of the patients report an antecedent upper respiratory illness. Inflammatory cardiovascular disease develops in 15% of patients. The diagnosis of CS requires the presence of ocular inflammation and inner ear dysfunction not explained by another illness. Because the differential diagnostic considerations in CS cross a broad spectrum of illnesses and toxicities, the proper assessment of CS and its management often requires the collaboration of numerous specialties. The exact etiology of CS remains a mystery, although immune mechanisms likely have a pivotal role in its pathogenesis. Treatment consists typically of corticosteroids and the judicious use of other immunosuppressive therapies.

Original languageEnglish (US)
Title of host publicationInflammatory Diseases of Blood Vessels
Subtitle of host publicationSecond Edition
Number of pages13
ISBN (Print)9781444338225
StatePublished - May 3 2012
Externally publishedYes


  • Aortitis
  • Autoimmune hearing loss
  • Cochlear hydrops
  • Cogan's syndrome
  • Interstitial keratitis
  • Oscillopsia
  • Vasculitis
  • Vertigo

ASJC Scopus subject areas

  • General Medicine


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