Cogan's Syndrome

Rex M. McCallum, E. William St. Clair

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Cogan's syndrome (CS) is characterized by interstitial keratitis, which rarely produces blindness, and recurrent Meniere's-like vestibulo-auditory events with frequent progression to hearing loss and deafness. It is a rare disease with a mean age of onset at 29 years. The mortality rate is unknown. Approximately half of the patients report an antecedent upper respiratory illness. Inflammatory cardiovascular disease develops in 15% of patients. The diagnosis of CS requires the presence of ocular inflammation and inner ear dysfunction not explained by another illness. Because the differential diagnostic considerations in CS cross a broad spectrum of illnesses and toxicities, the proper assessment of CS and its management often requires the collaboration of numerous specialties. The exact etiology of CS remains a mystery, although immune mechanisms likely have a pivotal role in its pathogenesis. Treatment consists typically of corticosteroids and the judicious use of other immunosuppressive therapies.

Original languageEnglish (US)
Title of host publicationInflammatory Diseases of Blood Vessels: Second Edition
PublisherWiley-Blackwell
Pages299-311
Number of pages13
ISBN (Print)9781444338225
DOIs
StatePublished - May 3 2012

Fingerprint

Cogan Syndrome
Keratitis
Deafness
Inner Ear
Blindness
Immunosuppressive Agents
Rare Diseases
Hearing Loss
Age of Onset
Adrenal Cortex Hormones
Cardiovascular Diseases
Inflammation
Mortality
Therapeutics

Keywords

  • Aortitis
  • Autoimmune hearing loss
  • Cochlear hydrops
  • Cogan's syndrome
  • Interstitial keratitis
  • Oscillopsia
  • Vasculitis
  • Vertigo

ASJC Scopus subject areas

  • Medicine(all)

Cite this

McCallum, R. M., & St. Clair, E. W. (2012). Cogan's Syndrome. In Inflammatory Diseases of Blood Vessels: Second Edition (pp. 299-311). Wiley-Blackwell. https://doi.org/10.1002/9781118355244.ch27

Cogan's Syndrome. / McCallum, Rex M.; St. Clair, E. William.

Inflammatory Diseases of Blood Vessels: Second Edition. Wiley-Blackwell, 2012. p. 299-311.

Research output: Chapter in Book/Report/Conference proceedingChapter

McCallum, RM & St. Clair, EW 2012, Cogan's Syndrome. in Inflammatory Diseases of Blood Vessels: Second Edition. Wiley-Blackwell, pp. 299-311. https://doi.org/10.1002/9781118355244.ch27
McCallum RM, St. Clair EW. Cogan's Syndrome. In Inflammatory Diseases of Blood Vessels: Second Edition. Wiley-Blackwell. 2012. p. 299-311 https://doi.org/10.1002/9781118355244.ch27
McCallum, Rex M. ; St. Clair, E. William. / Cogan's Syndrome. Inflammatory Diseases of Blood Vessels: Second Edition. Wiley-Blackwell, 2012. pp. 299-311
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