Cognitive decline in older Mexican Americans with diabetes

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17 Citations (Scopus)

Abstract

Objective: To examine social, demographic and health factors associated with cognitive decline over a seven-year period among older Mexican Americans with diabetes. Methods: A population-based sample of 808 noninstitutionalized Mexican Americans aged ≥65 years with diabetes who had a Mini-Mental State Examination (MMSE) >17 at baseline from the Hispanic Established Population for the Epidemiological Study of the Elderly (H-EPESE). Measurements included sociodemographics, diabetic treatment received (oral hypoglycemic or insulin), self-reported medical conditions, self-reported diabetes-related complications, high depressive symptoms and ADL limitations. Results: The mean MMSE score at baseline was 25.3 ± (SD=3.7). The rate of decline in cognitive function (MMSE) during the follow-up period was 0.37 point per year. Using general linear mixed models, we found that being male, and having high depressive symptoms and diabetic complications (kidney impairment, circulation problems or limb amputation) were factors significantly associated with greater declines in MMSE score over time. Conclusion: Circulation problems, kidney impairment and depression are the major factors associated with cognitive decline in older Mexican Americans with diabetes.

Original languageEnglish (US)
Pages (from-to)1840-1847
Number of pages8
JournalJournal of the National Medical Association
Volume98
Issue number11
StatePublished - Nov 2006

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Renal Circulation
Diabetes Complications
Depression
Activities of Daily Living
Amputation
Hispanic Americans
Hypoglycemic Agents
Cognition
Population
Epidemiologic Studies
Linear Models
Extremities
Demography
Insulin
Health
Cognitive Dysfunction
Therapeutics

Keywords

  • Cognitive decline
  • Diabetes
  • Elderly health
  • Mexican Americans

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Cognitive decline in older Mexican Americans with diabetes",
abstract = "Objective: To examine social, demographic and health factors associated with cognitive decline over a seven-year period among older Mexican Americans with diabetes. Methods: A population-based sample of 808 noninstitutionalized Mexican Americans aged ≥65 years with diabetes who had a Mini-Mental State Examination (MMSE) >17 at baseline from the Hispanic Established Population for the Epidemiological Study of the Elderly (H-EPESE). Measurements included sociodemographics, diabetic treatment received (oral hypoglycemic or insulin), self-reported medical conditions, self-reported diabetes-related complications, high depressive symptoms and ADL limitations. Results: The mean MMSE score at baseline was 25.3 ± (SD=3.7). The rate of decline in cognitive function (MMSE) during the follow-up period was 0.37 point per year. Using general linear mixed models, we found that being male, and having high depressive symptoms and diabetic complications (kidney impairment, circulation problems or limb amputation) were factors significantly associated with greater declines in MMSE score over time. Conclusion: Circulation problems, kidney impairment and depression are the major factors associated with cognitive decline in older Mexican Americans with diabetes.",
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T1 - Cognitive decline in older Mexican Americans with diabetes

AU - Czarnecki, Anna

AU - Al Snih al snih, Soham

AU - Raji, Mukaila

AU - Kuo, Yong Fang

AU - Markides, Kyriakos

PY - 2006/11

Y1 - 2006/11

N2 - Objective: To examine social, demographic and health factors associated with cognitive decline over a seven-year period among older Mexican Americans with diabetes. Methods: A population-based sample of 808 noninstitutionalized Mexican Americans aged ≥65 years with diabetes who had a Mini-Mental State Examination (MMSE) >17 at baseline from the Hispanic Established Population for the Epidemiological Study of the Elderly (H-EPESE). Measurements included sociodemographics, diabetic treatment received (oral hypoglycemic or insulin), self-reported medical conditions, self-reported diabetes-related complications, high depressive symptoms and ADL limitations. Results: The mean MMSE score at baseline was 25.3 ± (SD=3.7). The rate of decline in cognitive function (MMSE) during the follow-up period was 0.37 point per year. Using general linear mixed models, we found that being male, and having high depressive symptoms and diabetic complications (kidney impairment, circulation problems or limb amputation) were factors significantly associated with greater declines in MMSE score over time. Conclusion: Circulation problems, kidney impairment and depression are the major factors associated with cognitive decline in older Mexican Americans with diabetes.

AB - Objective: To examine social, demographic and health factors associated with cognitive decline over a seven-year period among older Mexican Americans with diabetes. Methods: A population-based sample of 808 noninstitutionalized Mexican Americans aged ≥65 years with diabetes who had a Mini-Mental State Examination (MMSE) >17 at baseline from the Hispanic Established Population for the Epidemiological Study of the Elderly (H-EPESE). Measurements included sociodemographics, diabetic treatment received (oral hypoglycemic or insulin), self-reported medical conditions, self-reported diabetes-related complications, high depressive symptoms and ADL limitations. Results: The mean MMSE score at baseline was 25.3 ± (SD=3.7). The rate of decline in cognitive function (MMSE) during the follow-up period was 0.37 point per year. Using general linear mixed models, we found that being male, and having high depressive symptoms and diabetic complications (kidney impairment, circulation problems or limb amputation) were factors significantly associated with greater declines in MMSE score over time. Conclusion: Circulation problems, kidney impairment and depression are the major factors associated with cognitive decline in older Mexican Americans with diabetes.

KW - Cognitive decline

KW - Diabetes

KW - Elderly health

KW - Mexican Americans

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