Cognitive deficits associated with a high-fat diet and insulin resistance are potentiated by overexpression of ecto-nucleotide pyrophosphatase phosphodiesterase-1

J. M. Kasper, A. J. Milton, A. E. Smith, F. Laezza, G. Taglialatela, J. D. Hommel, N. Abate

Research output: Contribution to journalArticle

8 Scopus citations


There is growing evidence that over consumption of high-fat foods and insulin resistance may alter hippocampal-dependent cognitive function. To study the individual contributions of diet and peripheral insulin resistance to learning and memory, we used a transgenic mouse line that overexpresses ecto-nucleotide pyrophosphatase phosphodiesterase-1 in adipocytes, which inhibits the insulin receptor. Here, we demonstrate that a model of peripheral insulin resistance exacerbates high-fat diet induced deficits in performance on the Morris Water Maze task. This finding was then reviewed in the context of the greater literature to explore potential mechanisms including triglyceride storage, adiponectin, lipid composition, insulin signaling, oxidative stress, and hippocampal signaling. Together, these findings further our understanding of the complex relationship among peripheral insulin resistance, diet and memory.

Original languageEnglish (US)
JournalInternational Journal of Developmental Neuroscience
StateAccepted/In press - Dec 19 2016


ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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