@article{d92df9ab18754b299e9433a234a983a3,
title = "Cognitive impairment in patients with heart failure: an international study",
abstract = "Aims: Cognitive impairment (CI) in heart failure (HF) patients has mostly been studied in single countries in specific health care settings. Sociodemographic and clinical predictors of the global CI and CI dimensions are still unclear. We described CI in a diverse HF population recruited in several countries and in different health care settings and investigated sociodemographic and clinical factors associated with the global and specific CI dimensions in HF patients. Methods and results: A secondary analysis from the baseline data of the Wii-HF trial. Patients (n = 605) were enrolled in Sweden, Italy, Israel, The Netherlands, Germany, and the United States. We used the Montreal Cognitive Assessment to evaluate CI and the 6 minute walk test (6MWT) to measure exercise capacity. Patients were on average 67 years old (SD, 12), and 86% were in New York Heart Association Class II and III. The mean Montreal Cognitive Assessment score was 24 (SD, 4), and 67% of patients had at least a mild CI. The item evaluating short-term memory had a considerable proportion of low scoring patients (28.1%). Worse CI was associated with patients' older age, lower education, and lower 6MWT scores (R2 = 0.27). CI dimension scores were differently associated with specific clinical and demographic variables, but the 6MWT scores were associated with five out of seven CI dimension scores. Conclusions: CI is an important problem in HF patients, with specific challenges in regard to memory. Exercise capacity is a modifiable factor that could be improved in HF patients with the potential to improve cognition and other outcomes in this population.",
keywords = "Cognitive impairment, Exercise capacity, Heart failure",
author = "Ercole Vellone and Oronzo Chial{\`a} and Josiane Boyne and Leonie Klompstra and Evangelista, {Lorraine S.} and Maria Back and {Ben Gal}, Tuvia and Jan M{\aa}rtensson and Anna Str{\"o}mberg and Tiny Jaarsma",
note = "Funding Information: This work was supported through the Swedish National Science Council (K2013‐69X‐22302‐01‐3, 2016‐01390), Swedish National Science Council/Swedish Research Council for Health, Working Life and Welfare (VR‐FORTE) 2014‐4100, The Swedish Heart and Lung Association E085/12, The Swedish Heart and Lung Foundation (20130340 and 20160439), the V{\aa}rdal Foundation (2014–0018), the Medical Research Council of Southeast Sweden (FORSS 474681). Funding Information: This work was supported through the Swedish National Science Council (K2013-69X-22302-01-3, 2016-01390), Swedish National Science Council/Swedish Research Council for Health, Working Life and Welfare (VR-FORTE) 2014-4100, The Swedish Heart and Lung Association E085/12, The Swedish Heart and Lung Foundation (20130340 and 20160439), the V?rdal Foundation (2014?0018), the Medical Research Council of Southeast Sweden (FORSS 474681). The following persons played a vital role in data collection. Norrk?ping: L Nestor, C Norrman, M Viklander, A Waldemar, RM Petterson; M W?rfman; J?nk?ping: E Lundberg, H Sk?ldb?ck, M Sahlin; Link?ping: A Gylling, M Huss, M Jonsson, P Wodlin, L Hjelmfors; Stockholm: E H?gglund, U Lennmark; Nyk?ping: E S?fstr?m; Italy: R Corsi, G Alberto Ortali; The Netherlands: HP Brunner-La Rocca, M Spanjers, A van de Voorde, G Cleuren; Israel: S Donanhirsh, Y Navon, V Yaari B. Avraham; Germany: A Hagenow, A Kuntzsch; and United States: J Ardo, J Nguyen, M Cacciata. Publisher Copyright: {\textcopyright} 2019 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology",
year = "2020",
month = feb,
day = "1",
doi = "10.1002/ehf2.12542",
language = "English (US)",
volume = "7",
pages = "46--53",
journal = "ESC Heart Failure",
issn = "2055-5822",
publisher = "The Heart Failure Association of the European Society of Cardiology",
number = "1",
}