Cold stress response in patients with severe burns after β-blockade

D. Honeycutt, R. Barrow, David Herndon

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Adrenergic receptor blockade has been shown to be of benefit in the treatment of adverse cardiovascular changes in patients with burns during the hypermetabolic phase. This article examines the stress response to cold exposure in adults and children with 33% to 95% total body surface area burns with and without β-blockade. Resting energy expenditures were measured by indirect calorimetry; the test subjects were exposed to mean temperatures of 27.5° C (room temperature) or 24.6° C (cold). The mean resting energy expenditure at ambient room temperature in patients with burns without β- blockade was 1411 ± 70 kcal/m2/day (mean ± SEM). This value was 142% of that predicted for normal control subjects without burns. When placed in a cold temperature, patients with burns significantly increased their resting energy expenditures by 160% of predicted values, whereas patients with similar burns and β-blockade increased their resting energy expenditures by 156%. Adults with septic burns had a mean resting energy expenditure 198% of the predicted value. These patients did not significantly increase their resting energy expenditures when they were exposed to cold either with or without β-blockade. Data suggest that patients with septic burns already have a maximal metabolic response and that cold stress does not further increase this response. Males, ages 17 to 54 years, were found to increase their resting energy expenditures by 11.4 kcal/m2/day for each percent total body surface area burn. We conclude that β-blockade with propranolol in therapeutic doses may be used in patients with burns without adversely affecting the cold stress response.

Original languageEnglish (US)
Pages (from-to)181-186
Number of pages6
JournalJournal of Burn Care and Rehabilitation
Volume13
Issue number2 I
StatePublished - 1992

Fingerprint

Cold-Shock Response
Burns
Energy Metabolism
Body Surface Area
Temperature
Indirect Calorimetry
Physiological Stress
Propranolol
Adrenergic Receptors

ASJC Scopus subject areas

  • Emergency Medicine
  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)

Cite this

Cold stress response in patients with severe burns after β-blockade. / Honeycutt, D.; Barrow, R.; Herndon, David.

In: Journal of Burn Care and Rehabilitation, Vol. 13, No. 2 I, 1992, p. 181-186.

Research output: Contribution to journalArticle

Honeycutt, D, Barrow, R & Herndon, D 1992, 'Cold stress response in patients with severe burns after β-blockade', Journal of Burn Care and Rehabilitation, vol. 13, no. 2 I, pp. 181-186.
Honeycutt, D. ; Barrow, R. ; Herndon, David. / Cold stress response in patients with severe burns after β-blockade. In: Journal of Burn Care and Rehabilitation. 1992 ; Vol. 13, No. 2 I. pp. 181-186.
@article{a5d28b54def848e0b9cd4a6321126229,
title = "Cold stress response in patients with severe burns after β-blockade",
abstract = "Adrenergic receptor blockade has been shown to be of benefit in the treatment of adverse cardiovascular changes in patients with burns during the hypermetabolic phase. This article examines the stress response to cold exposure in adults and children with 33{\%} to 95{\%} total body surface area burns with and without β-blockade. Resting energy expenditures were measured by indirect calorimetry; the test subjects were exposed to mean temperatures of 27.5° C (room temperature) or 24.6° C (cold). The mean resting energy expenditure at ambient room temperature in patients with burns without β- blockade was 1411 ± 70 kcal/m2/day (mean ± SEM). This value was 142{\%} of that predicted for normal control subjects without burns. When placed in a cold temperature, patients with burns significantly increased their resting energy expenditures by 160{\%} of predicted values, whereas patients with similar burns and β-blockade increased their resting energy expenditures by 156{\%}. Adults with septic burns had a mean resting energy expenditure 198{\%} of the predicted value. These patients did not significantly increase their resting energy expenditures when they were exposed to cold either with or without β-blockade. Data suggest that patients with septic burns already have a maximal metabolic response and that cold stress does not further increase this response. Males, ages 17 to 54 years, were found to increase their resting energy expenditures by 11.4 kcal/m2/day for each percent total body surface area burn. We conclude that β-blockade with propranolol in therapeutic doses may be used in patients with burns without adversely affecting the cold stress response.",
author = "D. Honeycutt and R. Barrow and David Herndon",
year = "1992",
language = "English (US)",
volume = "13",
pages = "181--186",
journal = "Journal of Burn Care and Research",
issn = "1559-047X",
publisher = "Lippincott Williams and Wilkins",
number = "2 I",

}

TY - JOUR

T1 - Cold stress response in patients with severe burns after β-blockade

AU - Honeycutt, D.

AU - Barrow, R.

AU - Herndon, David

PY - 1992

Y1 - 1992

N2 - Adrenergic receptor blockade has been shown to be of benefit in the treatment of adverse cardiovascular changes in patients with burns during the hypermetabolic phase. This article examines the stress response to cold exposure in adults and children with 33% to 95% total body surface area burns with and without β-blockade. Resting energy expenditures were measured by indirect calorimetry; the test subjects were exposed to mean temperatures of 27.5° C (room temperature) or 24.6° C (cold). The mean resting energy expenditure at ambient room temperature in patients with burns without β- blockade was 1411 ± 70 kcal/m2/day (mean ± SEM). This value was 142% of that predicted for normal control subjects without burns. When placed in a cold temperature, patients with burns significantly increased their resting energy expenditures by 160% of predicted values, whereas patients with similar burns and β-blockade increased their resting energy expenditures by 156%. Adults with septic burns had a mean resting energy expenditure 198% of the predicted value. These patients did not significantly increase their resting energy expenditures when they were exposed to cold either with or without β-blockade. Data suggest that patients with septic burns already have a maximal metabolic response and that cold stress does not further increase this response. Males, ages 17 to 54 years, were found to increase their resting energy expenditures by 11.4 kcal/m2/day for each percent total body surface area burn. We conclude that β-blockade with propranolol in therapeutic doses may be used in patients with burns without adversely affecting the cold stress response.

AB - Adrenergic receptor blockade has been shown to be of benefit in the treatment of adverse cardiovascular changes in patients with burns during the hypermetabolic phase. This article examines the stress response to cold exposure in adults and children with 33% to 95% total body surface area burns with and without β-blockade. Resting energy expenditures were measured by indirect calorimetry; the test subjects were exposed to mean temperatures of 27.5° C (room temperature) or 24.6° C (cold). The mean resting energy expenditure at ambient room temperature in patients with burns without β- blockade was 1411 ± 70 kcal/m2/day (mean ± SEM). This value was 142% of that predicted for normal control subjects without burns. When placed in a cold temperature, patients with burns significantly increased their resting energy expenditures by 160% of predicted values, whereas patients with similar burns and β-blockade increased their resting energy expenditures by 156%. Adults with septic burns had a mean resting energy expenditure 198% of the predicted value. These patients did not significantly increase their resting energy expenditures when they were exposed to cold either with or without β-blockade. Data suggest that patients with septic burns already have a maximal metabolic response and that cold stress does not further increase this response. Males, ages 17 to 54 years, were found to increase their resting energy expenditures by 11.4 kcal/m2/day for each percent total body surface area burn. We conclude that β-blockade with propranolol in therapeutic doses may be used in patients with burns without adversely affecting the cold stress response.

UR - http://www.scopus.com/inward/record.url?scp=0026657003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026657003&partnerID=8YFLogxK

M3 - Article

VL - 13

SP - 181

EP - 186

JO - Journal of Burn Care and Research

JF - Journal of Burn Care and Research

SN - 1559-047X

IS - 2 I

ER -