Collagen coating promotes biocompatibility of semiconductor nanoparticles in stratified LBL films

Vladimir A. Sinani; Dmitry S. Koktysh; Bo Geon Yun; Robert L. Matts; Todd C. Pappas; Massoud Motamedi; Stephanie N. Thomas; Nicholas A. Kotov

doi:10.1021/nl0255045

Collagen coating promotes biocompatibility of semiconductor nanoparticles in stratified LBL films

Vladimir A. Sinani, Dmitry S. Koktysh, Bo Geon Yun, Robert L. Matts, Todd C. Pappas, Massoud Motamedi, Stephanie N. Thomas, Nicholas A. Kotov

Research Services

Research output: Contribution to journal › Article › peer-review

173 Scopus citations

Abstract

Nanostructured thin films fabricated from semiconductor nanoparticles (NPs) are of great interest for biomedical applications, but NP materials based on heavy metals can be cytotoxic. In this work, the preparation of semiconductor NPs followed the protocol of layer-by-layer (LBL) assembly, which alleviates this problem. Collagen/poly(acrylic acid) bilayers were added to CdTe/ polycation LBL films to produce porous collagen bilayers. Such stratified multilayer systems showed successful cell attachment and survival while native NP films were strongly cytotoxic.

Original language	English (US)
Pages (from-to)	1177-1182
Number of pages	6
Journal	Nano Letters
Volume	3
Issue number	9
DOIs	https://doi.org/10.1021/nl0255045
State	Published - Sep 1 2003

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

Access to Document

10.1021/nl0255045

Cite this

@article{e71de32be3964391be8ed702fcf30be7,

title = "Collagen coating promotes biocompatibility of semiconductor nanoparticles in stratified LBL films",

abstract = "Nanostructured thin films fabricated from semiconductor nanoparticles (NPs) are of great interest for biomedical applications, but NP materials based on heavy metals can be cytotoxic. In this work, the preparation of semiconductor NPs followed the protocol of layer-by-layer (LBL) assembly, which alleviates this problem. Collagen/poly(acrylic acid) bilayers were added to CdTe/ polycation LBL films to produce porous collagen bilayers. Such stratified multilayer systems showed successful cell attachment and survival while native NP films were strongly cytotoxic.",

author = "Sinani, {Vladimir A.} and Koktysh, {Dmitry S.} and Yun, {Bo Geon} and Matts, {Robert L.} and Pappas, {Todd C.} and Massoud Motamedi and Thomas, {Stephanie N.} and Kotov, {Nicholas A.}",

year = "2003",

month = sep,

day = "1",

doi = "10.1021/nl0255045",

language = "English (US)",

volume = "3",

pages = "1177--1182",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

number = "9",

}

TY - JOUR

T1 - Collagen coating promotes biocompatibility of semiconductor nanoparticles in stratified LBL films

AU - Sinani, Vladimir A.

AU - Koktysh, Dmitry S.

AU - Yun, Bo Geon

AU - Matts, Robert L.

AU - Pappas, Todd C.

AU - Motamedi, Massoud

AU - Thomas, Stephanie N.

AU - Kotov, Nicholas A.

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Nanostructured thin films fabricated from semiconductor nanoparticles (NPs) are of great interest for biomedical applications, but NP materials based on heavy metals can be cytotoxic. In this work, the preparation of semiconductor NPs followed the protocol of layer-by-layer (LBL) assembly, which alleviates this problem. Collagen/poly(acrylic acid) bilayers were added to CdTe/ polycation LBL films to produce porous collagen bilayers. Such stratified multilayer systems showed successful cell attachment and survival while native NP films were strongly cytotoxic.

AB - Nanostructured thin films fabricated from semiconductor nanoparticles (NPs) are of great interest for biomedical applications, but NP materials based on heavy metals can be cytotoxic. In this work, the preparation of semiconductor NPs followed the protocol of layer-by-layer (LBL) assembly, which alleviates this problem. Collagen/poly(acrylic acid) bilayers were added to CdTe/ polycation LBL films to produce porous collagen bilayers. Such stratified multilayer systems showed successful cell attachment and survival while native NP films were strongly cytotoxic.

UR - http://www.scopus.com/inward/record.url?scp=0141684521&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141684521&partnerID=8YFLogxK

U2 - 10.1021/nl0255045

DO - 10.1021/nl0255045

M3 - Article

AN - SCOPUS:0141684521

SN - 1530-6984

VL - 3

SP - 1177

EP - 1182

JO - Nano Letters

JF - Nano Letters

IS - 9

ER -

Collagen coating promotes biocompatibility of semiconductor nanoparticles in stratified LBL films

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this