Collagen coating promotes biocompatibility of semiconductor nanoparticles in stratified LBL films

Vladimir A. Sinani, Dmitry S. Koktysh, Bo Geon Yun, Robert L. Matts, Todd C. Pappas, Massoud Motamedi, Stephanie N. Thomas, Nicholas A. Kotov

    Research output: Contribution to journalArticlepeer-review

    161 Scopus citations

    Abstract

    Nanostructured thin films fabricated from semiconductor nanoparticles (NPs) are of great interest for biomedical applications, but NP materials based on heavy metals can be cytotoxic. In this work, the preparation of semiconductor NPs followed the protocol of layer-by-layer (LBL) assembly, which alleviates this problem. Collagen/poly(acrylic acid) bilayers were added to CdTe/ polycation LBL films to produce porous collagen bilayers. Such stratified multilayer systems showed successful cell attachment and survival while native NP films were strongly cytotoxic.

    Original languageEnglish (US)
    Pages (from-to)1177-1182
    Number of pages6
    JournalNano Letters
    Volume3
    Issue number9
    DOIs
    StatePublished - Sep 1 2003

    ASJC Scopus subject areas

    • Bioengineering
    • Chemistry(all)
    • Materials Science(all)
    • Condensed Matter Physics
    • Mechanical Engineering

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