Colonic motility and transit in health and ulcerative colitis

S. Narasimha Reddy, Gabriele Bazzocchi, Simon Chan, Kathy Akashi, Javier Villanueva-Meyer, George Yanni, Ismael Mena, William J. Snape

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

Preprandial and postprandial colonic motility and transit (scintigraphy), with respect to the splenic flexure, were studied in 10 patients with ulcerative colitis and in 9 healthy subjects. The healthy subjects had a postprandial increase in intraluminal pressure that was significantly (P < 0.03) greater in the descending colon than in other regions of the colon. In ulcerative colitis, the pressure was decreased in all regions compared with healthy subjects, with no significant pressure gradient among different regions. In normal subjects, transit was quiescent during fasting; eating stimulated both antegrade and retrograde transit. In ulcerative colitis, transit was variable before as well as after the meal. Both healthy subjects and patients with ulcerative colitis had more rapid emptying from the splenic flexure into the sigmoid than into the transverse colon. More frequent, low-amplitude, postprandial propagating contractions occurred in ulcerative colitis (P < 0.05) than in healthy subjects. Propagating contractions were always antegrade and caused a rapid movement of the tracer into the sigmoid. In conclusion, ulcerative colitis is characterized by (a) decreased contractility, (b) increased low-amplitude propagating contractions, and (c) variable transit. These disturbances may accentuate the diarrhea in ulcerative colitis.

Original languageEnglish (US)
Pages (from-to)1289-1297
Number of pages9
JournalGastroenterology
Volume101
Issue number5
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

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Ulcerative Colitis
Healthy Volunteers
Health
Transverse Colon
Sigmoid Colon
Pressure
Descending Colon
Radionuclide Imaging
Meals
Diarrhea
Fasting
Colon
Eating

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Reddy, S. N., Bazzocchi, G., Chan, S., Akashi, K., Villanueva-Meyer, J., Yanni, G., ... Snape, W. J. (1991). Colonic motility and transit in health and ulcerative colitis. Gastroenterology, 101(5), 1289-1297. https://doi.org/10.1016/0016-5085(91)90079-Z

Colonic motility and transit in health and ulcerative colitis. / Reddy, S. Narasimha; Bazzocchi, Gabriele; Chan, Simon; Akashi, Kathy; Villanueva-Meyer, Javier; Yanni, George; Mena, Ismael; Snape, William J.

In: Gastroenterology, Vol. 101, No. 5, 01.01.1991, p. 1289-1297.

Research output: Contribution to journalArticle

Reddy, SN, Bazzocchi, G, Chan, S, Akashi, K, Villanueva-Meyer, J, Yanni, G, Mena, I & Snape, WJ 1991, 'Colonic motility and transit in health and ulcerative colitis', Gastroenterology, vol. 101, no. 5, pp. 1289-1297. https://doi.org/10.1016/0016-5085(91)90079-Z
Reddy SN, Bazzocchi G, Chan S, Akashi K, Villanueva-Meyer J, Yanni G et al. Colonic motility and transit in health and ulcerative colitis. Gastroenterology. 1991 Jan 1;101(5):1289-1297. https://doi.org/10.1016/0016-5085(91)90079-Z
Reddy, S. Narasimha ; Bazzocchi, Gabriele ; Chan, Simon ; Akashi, Kathy ; Villanueva-Meyer, Javier ; Yanni, George ; Mena, Ismael ; Snape, William J. / Colonic motility and transit in health and ulcerative colitis. In: Gastroenterology. 1991 ; Vol. 101, No. 5. pp. 1289-1297.
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