Colorado tick fever virus

An electron microscopic study

Frederick A. Murphy, Philip H. Coleman, Alyne K. Harrison, G. William Gary

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Colorado tick fever (CTF) virus was observed by ultrathin section and negative contrast electron microscopy. In sections of infected cultured cells and of mouse brain, virus particles (75 mμ in diameter) with electron dense cores were associated with intracytoplasmic granular matrices, arrays of intracytoplasmic filaments, and fine kinky threads. Occasionally, virus particles were enveloped by membranes of cytoplasmic organelles. Intranuclear filaments in dense arrays were frequently found in infected cells. In negative contrast preparations the virus was round, 80 mμ in diameter, with regularly spaced surface projections suggestive of cubic symmetry. Partial removal of surface components permitted the observation of an inner capsid 50 mμ in diameter. CTF virus was directly compared with reoviruses, which in several ultrastructural characteristics it resembles.

Original languageEnglish (US)
Pages (from-to)28-40
Number of pages13
JournalVirology
Volume35
Issue number1
StatePublished - May 1968

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Colorado tick fever virus
Virion
Electrons
Capsid
Organelles
Cultured Cells
Electron Microscopy
Cell Membrane
Observation
Viruses
Brain

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Murphy, F. A., Coleman, P. H., Harrison, A. K., & Gary, G. W. (1968). Colorado tick fever virus: An electron microscopic study. Virology, 35(1), 28-40.

Colorado tick fever virus : An electron microscopic study. / Murphy, Frederick A.; Coleman, Philip H.; Harrison, Alyne K.; Gary, G. William.

In: Virology, Vol. 35, No. 1, 05.1968, p. 28-40.

Research output: Contribution to journalArticle

Murphy, FA, Coleman, PH, Harrison, AK & Gary, GW 1968, 'Colorado tick fever virus: An electron microscopic study', Virology, vol. 35, no. 1, pp. 28-40.
Murphy FA, Coleman PH, Harrison AK, Gary GW. Colorado tick fever virus: An electron microscopic study. Virology. 1968 May;35(1):28-40.
Murphy, Frederick A. ; Coleman, Philip H. ; Harrison, Alyne K. ; Gary, G. William. / Colorado tick fever virus : An electron microscopic study. In: Virology. 1968 ; Vol. 35, No. 1. pp. 28-40.
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