Colorectal cancer in a population with endemic Schistosoma mansoni: Is this an at-risk population?

Khaled M. Madbouly, Anthony J. Senagore, Abir Mukerjee, Ahmed M. Hussien, M. A. Shehata, Philippa Navine, Conor P. Delaney, Victor W. Fazio

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Purpose: Chronic infection with schistosomiasis has been clearly associated with the development of bladder cancer, and infestation is associated with a high incidence of colorectal cancer in endemic populations. Despite this association, the potential role of alterations in tumor suppressor genes colorectal cancers has never been evaluated in an endemically infected population. The aim of this paper was to compare histopathologic and genetic changes in schistosomal colitis-associated colorectal cancer (SCC) with colorectal cancer in a group of patients from the same population not affected by the disease (NDCC). Materials and methods: Sixty patients were included in this study: SCC - 40, NDCC - 20. Data collected included age, sex, clinical presentation, presence of synchronous tumors, histopathology, and clinical stage. p53, DCC (deleted in colorectal cancer gene), and mismatch repair genes (MLH1 and MSH2) were studied using immunohistochemical staining. Results: Patients with SCC were significantly younger than the NDCC group (34.52±11.22 years vs 50.73±12.75 years, p=0.02). Mucinous adenocarcinoma occurred significantly more frequently in SCC (35 vs 10%, p=0.02). SCC tumors were more frequently stage III or IV, and significantly more synchronous tumors were present in the affected group (SCC-8/40 vs NDCC-1/20, p=0.05). p53 staining was far more frequent in SCC (SCC-32/40 vs NDCC-8/20, p=0.006). DCC expression was similar in two groups. There were only four cases, three in SCC and one in NDCC, that showed microsatellite instability. Conclusion: The data suggest that schistosomal colitis is more commonly associated with earlier onset of multicentric colorectal cancer, high percentage of mucinous adenocarcinoma, and presents at an advanced stage. The identification of a higher incidence of altered p53 expression in the SCC group raises the possibility of an association between schistosomiasis and alterations in p53 activation as an inciting event in colorectal cancer development.

Original languageEnglish (US)
Pages (from-to)175-181
Number of pages7
JournalInternational Journal of Colorectal Disease
Volume22
Issue number2
DOIs
StatePublished - Feb 2007
Externally publishedYes

Fingerprint

Schistosoma mansoni
Colorectal Neoplasms
Population
Mucinous Adenocarcinoma
Neoplasm Genes
Schistosomiasis
Colitis
Staining and Labeling
Neoplasms
Microsatellite Instability
DNA Mismatch Repair
Incidence
Tumor Suppressor Genes
Urinary Bladder Neoplasms
Gene Expression
Infection

Keywords

  • Colorectal cancer
  • DCC
  • P53
  • Schistosomiasis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Madbouly, K. M., Senagore, A. J., Mukerjee, A., Hussien, A. M., Shehata, M. A., Navine, P., ... Fazio, V. W. (2007). Colorectal cancer in a population with endemic Schistosoma mansoni: Is this an at-risk population? International Journal of Colorectal Disease, 22(2), 175-181. https://doi.org/10.1007/s00384-006-0144-3

Colorectal cancer in a population with endemic Schistosoma mansoni : Is this an at-risk population? / Madbouly, Khaled M.; Senagore, Anthony J.; Mukerjee, Abir; Hussien, Ahmed M.; Shehata, M. A.; Navine, Philippa; Delaney, Conor P.; Fazio, Victor W.

In: International Journal of Colorectal Disease, Vol. 22, No. 2, 02.2007, p. 175-181.

Research output: Contribution to journalArticle

Madbouly, KM, Senagore, AJ, Mukerjee, A, Hussien, AM, Shehata, MA, Navine, P, Delaney, CP & Fazio, VW 2007, 'Colorectal cancer in a population with endemic Schistosoma mansoni: Is this an at-risk population?', International Journal of Colorectal Disease, vol. 22, no. 2, pp. 175-181. https://doi.org/10.1007/s00384-006-0144-3
Madbouly, Khaled M. ; Senagore, Anthony J. ; Mukerjee, Abir ; Hussien, Ahmed M. ; Shehata, M. A. ; Navine, Philippa ; Delaney, Conor P. ; Fazio, Victor W. / Colorectal cancer in a population with endemic Schistosoma mansoni : Is this an at-risk population?. In: International Journal of Colorectal Disease. 2007 ; Vol. 22, No. 2. pp. 175-181.
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abstract = "Purpose: Chronic infection with schistosomiasis has been clearly associated with the development of bladder cancer, and infestation is associated with a high incidence of colorectal cancer in endemic populations. Despite this association, the potential role of alterations in tumor suppressor genes colorectal cancers has never been evaluated in an endemically infected population. The aim of this paper was to compare histopathologic and genetic changes in schistosomal colitis-associated colorectal cancer (SCC) with colorectal cancer in a group of patients from the same population not affected by the disease (NDCC). Materials and methods: Sixty patients were included in this study: SCC - 40, NDCC - 20. Data collected included age, sex, clinical presentation, presence of synchronous tumors, histopathology, and clinical stage. p53, DCC (deleted in colorectal cancer gene), and mismatch repair genes (MLH1 and MSH2) were studied using immunohistochemical staining. Results: Patients with SCC were significantly younger than the NDCC group (34.52±11.22 years vs 50.73±12.75 years, p=0.02). Mucinous adenocarcinoma occurred significantly more frequently in SCC (35 vs 10{\%}, p=0.02). SCC tumors were more frequently stage III or IV, and significantly more synchronous tumors were present in the affected group (SCC-8/40 vs NDCC-1/20, p=0.05). p53 staining was far more frequent in SCC (SCC-32/40 vs NDCC-8/20, p=0.006). DCC expression was similar in two groups. There were only four cases, three in SCC and one in NDCC, that showed microsatellite instability. Conclusion: The data suggest that schistosomal colitis is more commonly associated with earlier onset of multicentric colorectal cancer, high percentage of mucinous adenocarcinoma, and presents at an advanced stage. The identification of a higher incidence of altered p53 expression in the SCC group raises the possibility of an association between schistosomiasis and alterations in p53 activation as an inciting event in colorectal cancer development.",
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AU - Mukerjee, Abir

AU - Hussien, Ahmed M.

AU - Shehata, M. A.

AU - Navine, Philippa

AU - Delaney, Conor P.

AU - Fazio, Victor W.

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N2 - Purpose: Chronic infection with schistosomiasis has been clearly associated with the development of bladder cancer, and infestation is associated with a high incidence of colorectal cancer in endemic populations. Despite this association, the potential role of alterations in tumor suppressor genes colorectal cancers has never been evaluated in an endemically infected population. The aim of this paper was to compare histopathologic and genetic changes in schistosomal colitis-associated colorectal cancer (SCC) with colorectal cancer in a group of patients from the same population not affected by the disease (NDCC). Materials and methods: Sixty patients were included in this study: SCC - 40, NDCC - 20. Data collected included age, sex, clinical presentation, presence of synchronous tumors, histopathology, and clinical stage. p53, DCC (deleted in colorectal cancer gene), and mismatch repair genes (MLH1 and MSH2) were studied using immunohistochemical staining. Results: Patients with SCC were significantly younger than the NDCC group (34.52±11.22 years vs 50.73±12.75 years, p=0.02). Mucinous adenocarcinoma occurred significantly more frequently in SCC (35 vs 10%, p=0.02). SCC tumors were more frequently stage III or IV, and significantly more synchronous tumors were present in the affected group (SCC-8/40 vs NDCC-1/20, p=0.05). p53 staining was far more frequent in SCC (SCC-32/40 vs NDCC-8/20, p=0.006). DCC expression was similar in two groups. There were only four cases, three in SCC and one in NDCC, that showed microsatellite instability. Conclusion: The data suggest that schistosomal colitis is more commonly associated with earlier onset of multicentric colorectal cancer, high percentage of mucinous adenocarcinoma, and presents at an advanced stage. The identification of a higher incidence of altered p53 expression in the SCC group raises the possibility of an association between schistosomiasis and alterations in p53 activation as an inciting event in colorectal cancer development.

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