Colostrinin™

An oxidative stress modulator for prevention and treatment of age-related disorders

Istvan Boldogh, Marian L. Kruzel

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Colostrum-derived proline-rich polypeptide, also known as Colostrinin™ (CLN), has been shown to have a stabilizing effect on cognitive function in Alzheimer's disease patients. This complex action of CLN could be related to prevention of amyloid-β peptide aggregation, as shown in in vitro studies, and its impact on delicate cassettes of signaling pathways common to cellular redox regulation, proliferation and differentiation. Studies on cultured cells showed that CLN modulates intracellular levels of reactive oxygen species (ROS), via regulation of glutathione metabolism, activity of antioxidant enzymes and mitochondria function. Due to an improvement in senescence-associated mitochondrial dysfunction and a decrease in ROS generation, CLN decelerates the aging processes of both cultured cells and experimental animals. When given orally to mice, CLN increased the lifespan and improved various motor and sensory activities. Although the molecular basis by which CLN exerts its diverse effects are still under investigation, the regulatory effect on the cellular redox state via maintenance of mitochondrial function and modification of ROS-induced cell signaling seem to be of great importance. In this article, we examine experimental data pertinent to the mechanism of action, including a review of CLN's utility in the maintenance of physiological processes in which oxidative stress has an etiological role.

Original languageEnglish (US)
Pages (from-to)303-321
Number of pages19
JournalJournal of Alzheimer's Disease
Volume13
Issue number3
StatePublished - 2008

Fingerprint

Oxidative Stress
Reactive Oxygen Species
Oxidation-Reduction
Cultured Cells
Therapeutics
Maintenance
Physiological Phenomena
Peptides
Colostrum
Amyloid
Proline
Cognition
Glutathione
colostrinine
Alzheimer Disease
Mitochondria
Motor Activity
Antioxidants
Enzymes

Keywords

  • Age-related disorders
  • Alzheimer's disease
  • Amyloid-β
  • Immunomodulation
  • Oxidative stress
  • Proline-rich polypeptide

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

Cite this

Colostrinin™ : An oxidative stress modulator for prevention and treatment of age-related disorders. / Boldogh, Istvan; Kruzel, Marian L.

In: Journal of Alzheimer's Disease, Vol. 13, No. 3, 2008, p. 303-321.

Research output: Contribution to journalArticle

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