Colostrinin decreases hypersensitivity and allergic responses to common allergens

Istvan Boldogh, Leopoldo Aguilera-Aguirre, Attila Bacsi, Barun K. Choudhury, Alfredo Saavedra-Molina, Marian Kruzel

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background: Colostrinin™ (CLN), isolated from mothers' pre-milk fluid (colostrum), is a uniform mixture of low-molecular-weight, proline-rich polypeptides. CLN induces neurite outgrowth of pheochromocytoma cells, extends the lifespan of diploid fibroblast cells, inhibits β-amyloid-induced apoptosis and improves cognitive functions when administered to Alzheimer's disease patients. Objective: The aim of this study was to investigate potential allergic responses to CLN and its impact on allergic sensitization and inflammation caused by common allergens. Methods: We used a well-characterized mouse model of allergic airway inflammation. Changes in IgE/IgG1 and mucin levels, airway eosinophilia and hyperreactivity to methacholine were determined by ELISA, differential cell counting and whole-body plethysmography, respectively. Results: CLN did not increase IgE/IgG1 levels or induce cutaneous hypersensitivity reaction, airway inflammation and mucin production. Importantly, CLN significantly (p < 0.001) decreased IgE/IgG1 production, airway eosinophilia, mucin production and hypersensitivity induced by allergenic extracts from ragweed pollen grains and house dust mites. Conclusion: CLN itself is non-allergenic; however, it is effective in preventing allergic responses to known indoor and outdoor allergens. These data support the safe application of CLN and its potential use in the prevention of allergic inflammation in humans.

Original languageEnglish (US)
Pages (from-to)298-306
Number of pages9
JournalInternational Archives of Allergy and Immunology
Volume146
Issue number4
DOIs
StatePublished - Jul 1 2008

Keywords

  • Allergic inflammation
  • Colostrinin
  • Immunoglobulin E

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Boldogh, I., Aguilera-Aguirre, L., Bacsi, A., Choudhury, B. K., Saavedra-Molina, A., & Kruzel, M. (2008). Colostrinin decreases hypersensitivity and allergic responses to common allergens. International Archives of Allergy and Immunology, 146(4), 298-306. https://doi.org/10.1159/000121464