Colostrinin delays the onset of proliferative senescence of diploid murine fibroblast cells

Attila Bacsi, Mitchell Woodberry, Marian L. Kruzel, Istvan Boldogh

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Colostrinin™ (CLN), a uniform mixture of low-molecular weight, proline-rich polypeptides, induces neurite outgrowth of pheochromocytoma cells and inhibits beta amyloid-induced apoptosis. Moreover, its administration to patients with Alzheimer's disease resulted in improved cognitive functions. In this study, we investigated the impact of CLN on the lifespan of murine diploid fibroblast cells (MDF), an in vitro model for cellular aging. Here, we show that CLN significantly decelerates the senescence of cultured MDF and increases their population doubling levels. This action of CLN is associated with a decrease in the intracellular levels of reactive oxygen species, which may be due to senescence-associated mitochondrial dysfunction. These data suggest that CLN may delay the development of cellular aging at the level of the organism. Thus, CLN may be used in the prevention and/or therapy of diseases associated with aging processes.

Original languageEnglish (US)
Pages (from-to)93-101
Number of pages9
JournalNeuropeptides
Volume41
Issue number2
DOIs
StatePublished - Apr 2007

Fingerprint

Fibroblasts
Diploidy
Cells
Aging of materials
Cell Aging
Pheochromocytoma
Amyloid
Proline
Cognition
colostrinine
Reactive Oxygen Species
Alzheimer Disease
Molecular Weight
Molecular weight
Apoptosis
Peptides
Population

Keywords

  • Colostrinin™
  • Lifespan
  • Oxidative stress

ASJC Scopus subject areas

  • Endocrinology
  • Clinical Neurology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Biochemistry

Cite this

Colostrinin delays the onset of proliferative senescence of diploid murine fibroblast cells. / Bacsi, Attila; Woodberry, Mitchell; Kruzel, Marian L.; Boldogh, Istvan.

In: Neuropeptides, Vol. 41, No. 2, 04.2007, p. 93-101.

Research output: Contribution to journalArticle

Bacsi, Attila ; Woodberry, Mitchell ; Kruzel, Marian L. ; Boldogh, Istvan. / Colostrinin delays the onset of proliferative senescence of diploid murine fibroblast cells. In: Neuropeptides. 2007 ; Vol. 41, No. 2. pp. 93-101.
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