Combined ultrasound, optoacoustic and elasticity imaging

S. Y. Emelianov, S. R. Aglyamov, J. Shah, S. Sethuraman, W. G. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, A. Oraevsky

Research output: Contribution to journalConference articlepeer-review

54 Scopus citations


Combination of three complementary imaging technologies - ultrasound imaging, elastography, and optoacoustic imaging - is suggested for detection and diagnostics of tissue pathology including cancer. The fusion of these ultrasound-based techniques results in a novel imaging system capable of simultaneous imaging of the anatomy (ultrasound imaging), cancer-induced angiogenesis (optoacoustic imaging) and changes in mechanical properties (elasticity imaging) of tissue to uniquely identify and differentiate pathology at various stages. To evaluate our approach, analytical and numerical studies were performed using heterogeneous phantoms where ultrasonic, optical and viscoelastic properties of the materials were chosen to closely mimic soft tissue. The results of this study suggest that combined ultrasound-based imaging is possible and can provide more accurate, reliable and earlier detection and diagnosis of tissue pathology. In addition, monitoring of cancer treatment and guidance of tissue biopsy are possible with a combined imaging system.

Original languageEnglish (US)
Article number16
Pages (from-to)101-112
Number of pages12
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Issue number9
StatePublished - 2004
EventPhotons Plus Ultrasound: Imaging and Sensing - San Jose, CA, United States
Duration: Jan 25 2004Jan 26 2004


  • Advanced ultrasound imaging
  • Biopsy guidance
  • Cancer detection and diagnosis
  • Cancer-induced angiogenesis
  • Elasticity imaging
  • Medical imaging
  • Monitoring of cancer therapy
  • Optoacoustc imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Biomaterials


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