Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis

Charles G. Glabe, Rakez Kayed

Research output: Contribution to journalArticlepeer-review

280 Scopus citations

Abstract

Recent findings indicate that soluble amyloid oligomers may represent the primary pathologic species in degenerative diseases. These amyloid oligomers share common structural features and the ability to permeabilize membranes, suggesting that they also share a common primary mechanism of pathogenesis. Membrane permeabilization by amyloid oligomers may initiate a common group of downstream pathologic processes, including intracellular calcium dyshomeostasis, production of reactive oxygen species, altered signaling pathways, and mitochondrial dysfunction that represent key effectors of cellular dysfunction and cell death in amyloid-associated degenerative disease, such as sporadic inclusion-body myositis.

Original languageEnglish (US)
Pages (from-to)S74-S78
JournalNeurology
Volume66
Issue number2 SUPPL. 1
DOIs
StatePublished - Jan 2006
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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