Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

Rakez Kayed, Elizabeth Head, Jennifer L. Thompson, Theresa M. McIntire, Saskia C. Milton, Carl W. Cotman, Charles G. Glabel

Research output: Contribution to journalArticle

3002 Citations (Scopus)

Abstract

Soluble oligomers are common to most amyloids and may represent the primary toxic species of amyloids, like the Aβ peptide in Alzheimer's disease (AD). Here we show that all of the soluble oligomers tested display a common conformation-dependent structure that is unique to soluble oligomers regardless of sequence. The in vitro toxicity of soluble oligomers is inhibited by oligomer-specific antibody. Soluble oligomers have a unique distribution in human AD brain that is distinct from fibrillar amyloid. These results indicate that different types of soluble amyloid oligomers have a common structure and suggest they share a common mechanism of toxicity.

Original languageEnglish (US)
Pages (from-to)486-489
Number of pages4
JournalScience
Volume300
Issue number5618
DOIs
StatePublished - Apr 18 2003
Externally publishedYes

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Amyloid
Alzheimer Disease
Poisons
Peptides
Antibodies
Brain

ASJC Scopus subject areas

  • General

Cite this

Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., & Glabel, C. G. (2003). Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science, 300(5618), 486-489. https://doi.org/10.1126/science.1079469

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. / Kayed, Rakez; Head, Elizabeth; Thompson, Jennifer L.; McIntire, Theresa M.; Milton, Saskia C.; Cotman, Carl W.; Glabel, Charles G.

In: Science, Vol. 300, No. 5618, 18.04.2003, p. 486-489.

Research output: Contribution to journalArticle

Kayed, R, Head, E, Thompson, JL, McIntire, TM, Milton, SC, Cotman, CW & Glabel, CG 2003, 'Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis', Science, vol. 300, no. 5618, pp. 486-489. https://doi.org/10.1126/science.1079469
Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW et al. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 2003 Apr 18;300(5618):486-489. https://doi.org/10.1126/science.1079469
Kayed, Rakez ; Head, Elizabeth ; Thompson, Jennifer L. ; McIntire, Theresa M. ; Milton, Saskia C. ; Cotman, Carl W. ; Glabel, Charles G. / Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. In: Science. 2003 ; Vol. 300, No. 5618. pp. 486-489.
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