Comparative anthelmintic activity of Clerodendrum indicum & Alpinia galanga leaves

Objective: The current study was aimed to investigation of the anthelmintic potential of different crude extracts (MeOH extract and aqueous extract) of the leaves of Clerodendrum indicum & Alpinia galanga on Indian earth-worm (Pheretima posthuma). Methods: Three different concentrations (25, 50, 100 mg/ml) of each extract (MeOH and aqueous extract) were studied in activity which involved the determination of time of paralysis (vermifuge) and time of death (vermicidal) of the worms. Albendazole in same concentration as those of extract was included as standard reference and normal saline (0.9% NaCl) water with 1% CMC as control. Results: All the extracts exhibited significant anthelmintic activity at a concentration of 100 mg/ml. In both the cases it was found that MeOH extract gives better activity in comparison to aqueous extract. Results showed that Clerodendrum indicum leaf extract gives better anthelmintic activity than Alpinia galanga leaves at all the tested dosage. Conclusion: Findings of the experiment confirms that, both the plants having significant anthelmintic activity and hence the traditional claims of these plants are genuine.