Comparative effects of p-chlorophenylalanine, p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid

F. P. Miller, R. H. Cox, W. R. Snodgrass, R. P. Maickel

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Abstract

The time-course of effects of a single dose of p-chlorophenylanine on rat brain amines shows a significant lowering of serotonin (5HT) and 5-hydroxyindole-3-acetic acid (5HIAA) beginning on day 1 and lasting for about 8 days. In most brain areas, levels of norepinephrine (NE) are also lowered significantly on days 1 through 5. In contrast, both p-chloroamphetamine and p-chloro-N-methylamphetamine decrease brain 5HT and 5HIAA, beginning at 2-4 hr after dosage and continuing for > 4 days, with no depleting effect on brain NE.

Original languageEnglish (US)
Pages (from-to)435-436,IN3-IN4,437-442
JournalBiochemical Pharmacology
Volume19
Issue number2
DOIs
StatePublished - Feb 1970

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ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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