Comparative effects of p-chlorophenylalanine, p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid

F. P. Miller; R. H. Cox; W. R. Snodgrass; R. P. Maickel

doi:10.1016/0006-2952(70)90199-1

Comparative effects of p-chlorophenylalanine, p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid

F. P. Miller, R. H. Cox, W. R. Snodgrass, R. P. Maickel

Research output: Contribution to journal › Article › peer-review

342 Scopus citations

Abstract

The time-course of effects of a single dose of p-chlorophenylanine on rat brain amines shows a significant lowering of serotonin (5HT) and 5-hydroxyindole-3-acetic acid (5HIAA) beginning on day 1 and lasting for about 8 days. In most brain areas, levels of norepinephrine (NE) are also lowered significantly on days 1 through 5. In contrast, both p-chloroamphetamine and p-chloro-N-methylamphetamine decrease brain 5HT and 5HIAA, beginning at 2-4 hr after dosage and continuing for > 4 days, with no depleting effect on brain NE.

Original language	English (US)
Pages (from-to)	435-436,IN3-IN4,437-442
Journal	Biochemical Pharmacology
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/0006-2952(70)90199-1
State	Published - Feb 1970
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Pharmacology

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10.1016/0006-2952(70)90199-1

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Comparative effects of p-chlorophenylalanine, p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid. / Miller, F. P.; Cox, R. H.; Snodgrass, W. R. et al.
In: Biochemical Pharmacology, Vol. 19, No. 2, 02.1970, p. 435-436,IN3-IN4,437-442.

Research output: Contribution to journal › Article › peer-review

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title = "Comparative effects of p-chlorophenylalanine, p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid",

abstract = "The time-course of effects of a single dose of p-chlorophenylanine on rat brain amines shows a significant lowering of serotonin (5HT) and 5-hydroxyindole-3-acetic acid (5HIAA) beginning on day 1 and lasting for about 8 days. In most brain areas, levels of norepinephrine (NE) are also lowered significantly on days 1 through 5. In contrast, both p-chloroamphetamine and p-chloro-N-methylamphetamine decrease brain 5HT and 5HIAA, beginning at 2-4 hr after dosage and continuing for > 4 days, with no depleting effect on brain NE.",

author = "Miller, {F. P.} and Cox, {R. H.} and Snodgrass, {W. R.} and Maickel, {R. P.}",

note = "Funding Information: * Supported in part by USPHS grant MH-14658. {\textquoteleft}t Taken in part from a thesis submitted by F. P. Miller to the Graduate School in partial fulfillment of the requirements for the Ph.D. degree, Department of Pharmacology, Indiana University, November 1968. $ Present address: Lakeside Laboratories, Milwaukee, Wise. 53201.",

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AU - Snodgrass, W. R.

AU - Maickel, R. P.

N1 - Funding Information: * Supported in part by USPHS grant MH-14658. ‘t Taken in part from a thesis submitted by F. P. Miller to the Graduate School in partial fulfillment of the requirements for the Ph.D. degree, Department of Pharmacology, Indiana University, November 1968. $ Present address: Lakeside Laboratories, Milwaukee, Wise. 53201.

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AB - The time-course of effects of a single dose of p-chlorophenylanine on rat brain amines shows a significant lowering of serotonin (5HT) and 5-hydroxyindole-3-acetic acid (5HIAA) beginning on day 1 and lasting for about 8 days. In most brain areas, levels of norepinephrine (NE) are also lowered significantly on days 1 through 5. In contrast, both p-chloroamphetamine and p-chloro-N-methylamphetamine decrease brain 5HT and 5HIAA, beginning at 2-4 hr after dosage and continuing for > 4 days, with no depleting effect on brain NE.

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Comparative effects of p-chlorophenylalanine, p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid

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