Comparative effects of p-chlorophenylalanine, p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid

F. P. Miller, R. H. Cox, W. R. Snodgrass, R. P. Maickel

Research output: Contribution to journalArticle

270 Citations (Scopus)

Abstract

The time-course of effects of a single dose of p-chlorophenylanine on rat brain amines shows a significant lowering of serotonin (5HT) and 5-hydroxyindole-3-acetic acid (5HIAA) beginning on day 1 and lasting for about 8 days. In most brain areas, levels of norepinephrine (NE) are also lowered significantly on days 1 through 5. In contrast, both p-chloroamphetamine and p-chloro-N-methylamphetamine decrease brain 5HT and 5HIAA, beginning at 2-4 hr after dosage and continuing for > 4 days, with no depleting effect on brain NE.

Original languageEnglish (US)
JournalBiochemical Pharmacology
Volume19
Issue number2
DOIs
StatePublished - 1970
Externally publishedYes

Fingerprint

p-Chloroamphetamine
Fenclonine
Acetic Acid
Rats
Brain
Serotonin
Norepinephrine
Amines
5-hydroxyindole
chlormethamphetamine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Comparative effects of p-chlorophenylalanine, p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid. / Miller, F. P.; Cox, R. H.; Snodgrass, W. R.; Maickel, R. P.

In: Biochemical Pharmacology, Vol. 19, No. 2, 1970.

Research output: Contribution to journalArticle

@article{b30d6103e38941b0860d73d3202f5fd6,
title = "Comparative effects of p-chlorophenylalanine, p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid",
abstract = "The time-course of effects of a single dose of p-chlorophenylanine on rat brain amines shows a significant lowering of serotonin (5HT) and 5-hydroxyindole-3-acetic acid (5HIAA) beginning on day 1 and lasting for about 8 days. In most brain areas, levels of norepinephrine (NE) are also lowered significantly on days 1 through 5. In contrast, both p-chloroamphetamine and p-chloro-N-methylamphetamine decrease brain 5HT and 5HIAA, beginning at 2-4 hr after dosage and continuing for > 4 days, with no depleting effect on brain NE.",
author = "Miller, {F. P.} and Cox, {R. H.} and Snodgrass, {W. R.} and Maickel, {R. P.}",
year = "1970",
doi = "10.1016/0006-2952(70)90199-1",
language = "English (US)",
volume = "19",
journal = "Biochemical Pharmacology",
issn = "0006-2952",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Comparative effects of p-chlorophenylalanine, p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid

AU - Miller, F. P.

AU - Cox, R. H.

AU - Snodgrass, W. R.

AU - Maickel, R. P.

PY - 1970

Y1 - 1970

N2 - The time-course of effects of a single dose of p-chlorophenylanine on rat brain amines shows a significant lowering of serotonin (5HT) and 5-hydroxyindole-3-acetic acid (5HIAA) beginning on day 1 and lasting for about 8 days. In most brain areas, levels of norepinephrine (NE) are also lowered significantly on days 1 through 5. In contrast, both p-chloroamphetamine and p-chloro-N-methylamphetamine decrease brain 5HT and 5HIAA, beginning at 2-4 hr after dosage and continuing for > 4 days, with no depleting effect on brain NE.

AB - The time-course of effects of a single dose of p-chlorophenylanine on rat brain amines shows a significant lowering of serotonin (5HT) and 5-hydroxyindole-3-acetic acid (5HIAA) beginning on day 1 and lasting for about 8 days. In most brain areas, levels of norepinephrine (NE) are also lowered significantly on days 1 through 5. In contrast, both p-chloroamphetamine and p-chloro-N-methylamphetamine decrease brain 5HT and 5HIAA, beginning at 2-4 hr after dosage and continuing for > 4 days, with no depleting effect on brain NE.

UR - http://www.scopus.com/inward/record.url?scp=49849110443&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49849110443&partnerID=8YFLogxK

U2 - 10.1016/0006-2952(70)90199-1

DO - 10.1016/0006-2952(70)90199-1

M3 - Article

VL - 19

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

SN - 0006-2952

IS - 2

ER -