Comparative evaluation of antipruritic protocols in acute burns. the emerging value of gabapentin in the treatment of burns pruritus

Ioannis Goutos, Mohammed Eldardiri, Aadil A. Khan, Peter Dziewulski, Patricia M. Richardson

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Pruritus is a distressing symptom in burns rehabilitation and its treatment represents a challenge for the multidisciplinary burns team. We conducted a comparative study of two different therapeutic approaches in hospitalized burns patients using a combination of pharmacological agents. The observed symptomatic response to gabapentin as monotherapy as well as in combination therapy with two antihistamines was higher than chlorpheniramine alone and in combination with another two antihistamines (t = 3.70, df = 89, P < .001 for monotherapy and χ = 12.2, df = 1, P = .001 for polytherapy). Patients with higher initial itch scores needed a combination of pharmacologic agents for effective symptomatic relief. A linear regression model showed that the likelihood of failure of monotherapy was marginally associated with decreasing patient age (P = .013) and increasing TBSA (P = .021, sum of square = 1.986, df = 2, P = .04). A combined approach using centrally and peripherally acting agents is most effective in the treatment of acute burns pruritus.

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
JournalJournal of Burn Care and Research
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

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Antipruritics
Pruritus
Burns
Histamine Antagonists
Linear Models
Chlorpheniramine
Therapeutics
Rehabilitation
Pharmacology
gabapentin

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Rehabilitation

Cite this

Comparative evaluation of antipruritic protocols in acute burns. the emerging value of gabapentin in the treatment of burns pruritus. / Goutos, Ioannis; Eldardiri, Mohammed; Khan, Aadil A.; Dziewulski, Peter; Richardson, Patricia M.

In: Journal of Burn Care and Research, Vol. 31, No. 1, 01.01.2010, p. 57-63.

Research output: Contribution to journalArticle

Goutos, Ioannis ; Eldardiri, Mohammed ; Khan, Aadil A. ; Dziewulski, Peter ; Richardson, Patricia M. / Comparative evaluation of antipruritic protocols in acute burns. the emerging value of gabapentin in the treatment of burns pruritus. In: Journal of Burn Care and Research. 2010 ; Vol. 31, No. 1. pp. 57-63.
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