Comparative neurovirulence and latency of hsv₁ and hsv₂ following footpad inoculation in mice

The effect of virus dose and animal age on the appearance of acute and latent neurologic infection by HSV₁ and HSV₂ was studied in Balb/c and ICR mice inoculated in the footpad. At low viral doses HSV₂ was found to be 1,500 times more neurovirulent than HSV₁. At high doses there was no difference in neurovirulence. Age‐acquired resistance to disease was shown to be less complete with HSV₂ than with HSV₁. Neurovirulence was shown to be associated with spread of infection to the spinal ganglia. The data indicate that the factor(s) responsible for the differential neurovirulence of these two viruses is related to events at the level of the footpad and/or sciatic nerve.