Comparative neurovirulence and latency of HSV1 and HSV2 following footpad inoculation in mice

R. R. McKendall

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The effect of virus dose and animal age on the appearance of acute and latent neurologic infection by HSV1 and HSV2 was studied in BALB/C and ICR mice inoculated in the footpad. At low viral doses HSV2 was found to be 1,500 times more neurovirulent than HSV1. At high doses there was no difference in neurovirulence. Age-acquired resistance to disease was shown to be less complete with HSV2 than with HSV1. Neurovirulence was shown to be associated with spread of infection to the spinal ganglia. The data indicate that the factor(s) responsible for the differential neurovirulence of these two viruses is related to events at the level of the footpad and/or sciatic nerve.

Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalJournal of Medical Virology
Volume5
Issue number1
StatePublished - 1980

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Inbred BALB C Mouse
Viruses
Inbred ICR Mouse
Disease Resistance
Spinal Ganglia
Sciatic Nerve
Infection
Nervous System

ASJC Scopus subject areas

  • Virology

Cite this

Comparative neurovirulence and latency of HSV1 and HSV2 following footpad inoculation in mice. / McKendall, R. R.

In: Journal of Medical Virology, Vol. 5, No. 1, 1980, p. 25-32.

Research output: Contribution to journalArticle

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