Comparative proteome analysis by two-dimensional gel-electrophoresis in combination with mass spectrometry in a rat model of schizophrenia

Linda M. Paulson, Peter Martin, Carol L. Nilsson, Elisabeth Ljung, Ann Brinkmalm-Westman, Kaj Blennow, Pia Davidsson

Research output: Contribution to conferencePaper

Abstract

The comparative analysis of protein in schizophrenia using two-dimensional gel-electrophoresis in combination with mass spectrometry (MS) was discussed. The changes in the glutamate transmission played an important role in the pathophysiology of schizophrenia. The protein expressions were compared in thalamus in eight MK-801 treated rats and eight controls. Results show that MK-801 treatment of rats represents a model useful in search for antipsychotic compounds which diminishes the development of biochemical disturbances in schizophrenia.

Original languageEnglish (US)
Pages217-218
Number of pages2
StatePublished - Dec 1 2002
EventProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
Duration: Jun 2 2002Jun 6 2002

Other

OtherProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period6/2/026/6/02

ASJC Scopus subject areas

  • Spectroscopy

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    Paulson, L. M., Martin, P., Nilsson, C. L., Ljung, E., Brinkmalm-Westman, A., Blennow, K., & Davidsson, P. (2002). Comparative proteome analysis by two-dimensional gel-electrophoresis in combination with mass spectrometry in a rat model of schizophrenia. 217-218. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.